Guesthouse vacation rentals in Durham County

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Top-rated guesthouse rentals in Durham County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Durham

5 out of 5 average rating, 420 reviews

Light-filled Guesthouse Near Duke

Second floor of recently-built garage apartment in a charming, peaceful Durham neighborhood. Twenty minutes to RDU Airport, five minutes to Duke's East Campus and ten minutes to West Campus, we are an easy walk to a range of locally-owned restaurants. Lovely, light-filled apartment has a bedroom, full kitchen and living area, bathroom, private entrance, and patio with seating. Occasionally, we may have first-floor space available at extra cost. Well-behaved pets welcome. See below for fees.

Guest favorite

Guesthouse in Durham

4.96 out of 5 average rating, 78 reviews

Little House Old North Durham

Welcome to our little house in Old North Durham. The 300 square foot studio guest house sits behind our Bungalow in a centrally located historic neighborhood. It is a 15-20 minute walk to Durham's vibrant Central Park District and a little further to downtown. Close by restaurants, music, movies and shows. Sleeps 2 comfortably on queen bed, and up to 2 additional on a convertible couch from IKEA. Living area joins kitchen. Bedroom is divided by partial wall. Vaulted ceilings create openness.

Guest favorite

Guesthouse in Durham

4.95 out of 5 average rating, 292 reviews

Modern Cottage With a Vintage Twist Near Downtown

Come stay at our modern vintage guesthouse in Historic Trinity Park. Our cottage has all modern appliances with vintage fixtures. This 380 square foot cottage is located in a very lively and safe neighborhood just minutes from downtown Durham. Walk one mile on the Ellerbe creek trail to downtown and enjoy all the great entertainment Durham has to offer. Walk 1.5 mile to 9th street restaurants and shops 1 mile to Central Park and farmers market <1 mile to bars and restaurants on geer street

Guest favorite

Guesthouse in Durham

4.98 out of 5 average rating, 108 reviews

Great Guesthouse Studio Suite w/ hot tub & pool!

Book now & enjoy the pool, balcony & luxury high-end hot tub. Open 24hrs, exclusively for guest use. We welcome you to our little piece of paradise, not far from downtown Durham & Raleigh close to RDU. We offer a well-appointed studio, meticulously cleaned, with a queen Tempurpedic mattress, premium linens, fireplace, full kitchen, washer/dryer, 2 smart TV's & high speed wifi. *Please be aware* Due to allergies & health risks, we are unable to accommodate any animals. Sorry :-(

Guest favorite

Guesthouse in Durham

4.95 out of 5 average rating, 150 reviews

Spotless Scent & Mold-Free Guesthouse Near Duke!

New-construction (2022) spotlessly clean farmhouse-style guesthouse is 3 mins to Duke, 15 mins to UNC and 25 mins to Raleigh. Perfect for an RTP work trip or weekend alumni or family/student visit. Explore Durham (8 min drive to downtown Durham, DPAC, American Tobacco, etc.) or anywhere in the Triangle from this South Durham location in the charming Tuscaloosa-Lakewood neighborhood. Walking distance to Cocoa Cinnamon coffee shop and restaurants serving breakfast, lunch and dinner.

Guest favorite

Guesthouse in Durham

5 out of 5 average rating, 78 reviews

Delightfully Durham: Guesthouse with Kitchen!

Enjoy a peaceful stay only 3 miles from the heart of downtown Durham! Whether you're in town for work or to explore the area, this sunny and private guesthouse is a great place to get to know this gem of a city. 3 minutes from: - The Museum of Life & Science - The Ellerbee Creek Trailhead (paved w/ bike access to downtown) - Duke Regional Hospital 10 minutes from: - Duke University - Downtown Durham - Local Shopping & Dining (9th St., Foster St., Brightleaf District)

Superhost

Guesthouse in Durham

4.85 out of 5 average rating, 178 reviews

Lovely Studio with King Sized Trmpur-Pedic

Experience the beauty of Duke Forest in your back yard! Cozy and quiet in the trees, yet 2 miles from Duke University. King sized tempur-pedic for an amazing nights sleep. Our wonderful studio apartment boasts a well-equipped kitchenette, Roku with Hulu, Netflix included. A beautiful, private deck with panoramic views of Duke Forest. Walk right onto Sheperd's Trail, curated by Duke University, from the back yard. 2 miles to Duke Hospital. 3 miles to downtown Durham.

Guest favorite

Guesthouse in Durham

4.96 out of 5 average rating, 71 reviews

Duplex filled with natural light

A stylish, modern, and beautiful alley guesthouse that is located just 2 blocks from Duke's East Campus and 4 blocks from downtown Durham. The apartment is located in the historic Trinity Park Neighborhood in Durham. The apartment has a top of the line finish, hardwood floors, appliances, and furniture. The loft area is equipped with a standing desk and monitor and 2 Yoga matts, and it is ideal for working professionals visiting the area. Built: 2023

Guest favorite

Guesthouse in Durham

4.96 out of 5 average rating, 823 reviews

Cozy Tiny House in the Trees in the heart of Durm

You'll sleep in a loft nestled in the trees, and wake up to the songs of the morning birds. Super comfy and whimsical, the tiny house has everything you'll need in 120 TINY square feet of charm, right in our backyard in case you need anything at all. The space can accommodate a max of two guests. * This cozy spot is for folks who like it simple, small, rustic and sweet. * * Intentionally, there are no window coverings except for on the kitchen window.*

Guest favorite

Guesthouse in Durham

4.93 out of 5 average rating, 80 reviews

Studio on Tobacco Road

Whether you're coming to work or play, Studio on Tobacco Road is a perfectly positioned launch pad to experience Durham & Chapel Hill. Just 6 miles to Downtown Durham's renowned breweries & culinary scene, experience its creative arts culture & explore its rich history. Minutes from your home court, 4 miles to Duke. 5 miles to UNC. All from a beautifully designed studio on a quiet, nature-rich landscape less than a mile from Duke Forest.

Superhost

Guesthouse in Durham

4.83 out of 5 average rating, 18 reviews

Guest House

Enjoy the simplicity of this quiet and central place. With separate entrance and parking for a vehicle, with everything you need to make your stay more enjoyable. With a queen bed, wifi, Netflix, A/C, cooking utensils, and many more services, which we offer as hosts: private transportation to places in the city or airport, we rent water bikes we take them and pick up at the lake of your preference, grill rental for your outdoor meals.

Guest favorite

Guesthouse in Durham

4.99 out of 5 average rating, 180 reviews

Cute & Cozy Poolside Hideaway Near Duke & UNC

Tucked away in the back of our 1927 property sits The Sidekick, a thoughtfully restored carriage house surrounded by peaceful woods & grand homes. Part cowboy clubhouse, part restful retreat, The Sidekick is a conveniently-located getaway for couples, solo travelers, or small groups. Take a dip in the saline pool, lounge in the mature garden, or just rest your sleepy head on luxurious linens in your sweet lil' loft bedroom.