Vacation rentals with lake access in Pickens County

Find and book unique lake access rentals on Airbnb

Top-rated lake access rentals in Pickens County

Guests agree: these lake access rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guest suite in Greenville

4.9 out of 5 average rating, 273 reviews

intimate lakefront luxury suite 6mi from dt GVL

MINI PRIVATE OASIS. 6 MILES TO DOWNTOWN GREENVILLE! LAKEFRONT + PRIVATE DOCK NY Times #1 AMERICAN CITY! Experience modern luxury in your serene private mini suite. Please note: the suite is located as an extension of classic Scandinavian chalet - no shared spaces, 1 shared soundproofed wall. 6mi downtown Greenville, 5mi Traveler’s Rest - Private dock / paddleboard rental available - Private entrance & flower-friendly patio - 43” Roku TV - Charcoal grill, fire pit - - Blackout curtains

Guest favorite

Home in Easley

4.9 out of 5 average rating, 299 reviews

“Lake House Paradise” Waterfront Oasis

STORM UPDATE: The lake suffered a broken dam and the water level is down... the dock suffered damage from the flooding and is unusable. “Lake Paradise” is exquisitely furnished with 2 bedrooms and 1 and a half baths. Your Master Suite has its own screened in porch with private lake access. Wake up from your master suite to views of the water. Your Master Bathroom has a large luxury marble shower. Visit Greenville SC's downtown just 15 minutes away. Clemson football Stadium is 20 miles away.

Guest favorite

Cabin in Six Mile

4.97 out of 5 average rating, 101 reviews

Beautiful cabin retreat at Lake Keowee

Charming, remodeled cabin with loft across from Lake Keowee. Perfect to unwind, recharge, and create memories in this idyllic retreat. Centrally located to Six Mile, Salem, Seneca, Clemson, Walhalla, and the numerous state parks, trails, and waterfalls! Quaint community has a private pool with facilities and outdoor shower. We also have a private, community day dock across the street for easy lake access, fishing, and swimming. Less than 5 minutes is Warpath Landing a public boat ramp.

Guest favorite

Home in Seneca

4.99 out of 5 average rating, 186 reviews

Lakeside @ Lake Hartwell in Clemson, SC 🐟🌅🚤

Lake lovers and college football fans...you will LOVE this house! Lots of privacy, huge kitchen, dock, fire pit, gas grill, kayaks, and more! Beautiful Lake Hartwell home… where 1000 miles of shore awaits you! Our home is located just minutes away from Clemson, Seneca, Anderson, and more! Just 25 steps to your private dock, and 7 miles/ 10 mins from Death Valley (Memorial Stadium!) 4 bedrooms, and 3 full bathrooms. You must be at least 25 to rent. NO pets allowed, sorry! No fireworks.

Guest favorite

Condo in Salem

4.96 out of 5 average rating, 125 reviews

Beautiful Lake Keowee Condo with great Amenities

"Boasting lake views, a fully equipped kitchen, and resort-style amenities, this 2-bedroom, 2-bath Salem vacation rental condo in Keowee Key will have you experiencing the true meaning of life on the lake. Cool off with a dip in the community's outdoor pool which sits right next to the marina where you can rent a boat for a day out on the water. Tee up a round of golf on the renovated 18-hole course, walk along the trails of Oconee State Park, or catch a football game at Clemson University!"

Guest favorite

Home in Seneca

4.95 out of 5 average rating, 161 reviews

Private lake setting close to Clemson University

House is located in a private community yet only 2.5 miles to Death Valley and Clemson. Enjoy a walk down to the lake or relax on the back deck. WIFI is included with access to Hulu and Disney+. Kid friendly as well. Property is also within 1.2 miles of Oconee Airport, 0.7 miles to a dock, 1.5 miles to the grocery store, and less than 1.3 miles to Y beach public parking (avoid game day traffic if you are coming in for football). Close to everything in Oconee, Pickens and Anderson Counties.

Superhost

Home in Six Mile

4.85 out of 5 average rating, 221 reviews

House on Lake Keowee swim beach in cove w/ Dock

This two story home is located at the end of a very quiet cove with plenty of water. The beach has a fresh 6 inches of sand installed for the lake season. The walk to the lake is very short on an almost flat surface. The home will accommodate a family up to six people. The house has two floors. The main floor has a large living room with plenty of comfortable seating and satellite TV service provided. The entire main floor has hard woods along with the Master Bed Room and bed room #2.

Guest favorite

Cabin in Six Mile

4.93 out of 5 average rating, 147 reviews

Lake Keowee, Waterfront Cabin, 2-Story Dock!

Beautiful cabin 15 min from Clemson Stadium. Brand new to the rental market. Boasting cathedral ceilings, this home offers an open floor plan for everyone to gather. Sleeping 10 with 4 bedrooms and 3.5 bathrooms and 2 living rooms, there is space for everyone. Steep incline from lake to house with paved stairs. Tram from deck to dock! Fire pit with wood provided. Large deck and covered porch. Large covered dock for your boat with 650 sq. ft. second floor sundeck. 2 car garage.Hot Tub!

Guest favorite

Cabin in Sunset

4.87 out of 5 average rating, 154 reviews

Bear Creek Cabin near Clemson, Brevard, Cashiers

You will fall in love with this hidden gem on 7 private acres nestled in the Jocassee Gorges, the only true Rain Forest east of the Rockies- adjoining 50,000 acres of DNR Wildlife management area. Excellent Mountain get-away for those seeking a relaxing peaceful setting. Wildlife galore (black bear, dear, turkey), hiking, kayaking, Foothills Trail, Palmetto Trail, Sassafras Mountain, Victoria Valley Vineyards, waterfalls, and more! Trout fishing is perfect on the Little Estatooe too!

Guest favorite

Guest suite in Greenville

5 out of 5 average rating, 175 reviews

Cozy, Cute & Clean Cottage on Saluda Lake

Stunning lake views from private covered deck with daily western sunsets. Large dock to sit, sun, read or fish. Two kayaks with life vests available to tour the water. Saluda Lake is said to be one of Greenville's best kept secrets. Though a small 331 acre lake, the nearly 2 mile river to the 1920's working dam is great water to boat and fish. 13 mins to main street Greenville; 5 mins to Furman University; 45 mins to Clemson University or Lake Hartwell area. 5 mins to grocery stores.

Guest favorite

Shipping container in Easley

4.99 out of 5 average rating, 231 reviews

Lakefront container home | romantic + secluded

Start your next adventure at The Hive at Addison Farms! Upon arrival, you will be greeted with an incredible, picturesque view of Saluda Lake. This carefully designed romantic retreat is the ultimate getaway to unwind, reconnect, and relax. The Hive is conveniently located less than 20 mins. from Downtown Greenville, making it the perfect destination for a secluded weekend away, yet close enough to explore the wonderful places and activities in Upstate, SC.

Guest favorite

Home in Easley

4.91 out of 5 average rating, 145 reviews

Large lake house - 15 min to Downtown Greenville

Luxurious 5000 sq ft 3-story lake house in serene neighborhood, 15 min to downtown Greenville. Sleeps 12 in 9 beds, 4.5 baths. Enjoy pool table/bar, private dock with swim platform, inflatable toys and 2 stand up paddle boards. Stunning views, 3-car garage, lake-side fire pit, grill. Executive suite with office space, Primary suit with lake views. Perfect for relaxation, water activities, and cherished memories. Book now for an unforgettable escape!