Mansion vacation rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama mansion rentals
Mansion rentals with a pool
Villa in Panamá
4.98 out of 5 average rating, 49 reviewsBeautiful House in Panama w/ King Beds + Pool
Villa in Panamá
5.0 out of 5 average rating, 32 reviewsBreathtaking Views Mansion w/King Beds
Home in Río Hato
4.95 out of 5 average rating, 75 reviewsSpectacular beachfront house in Buenaventura!
Villa in Portobelo
5.0 out of 5 average rating, 43 reviewsEntire Villa with pool in front of beach!
Home in Playa Bluff
5.0 out of 5 average rating, 18 reviewsJungle House 100m from the beach
Home in San Carlos
4.93 out of 5 average rating, 89 reviewsBeach House-Ocean View Rooftop Jacuzzi & Pool
Apartment in Río Hato
5.0 out of 5 average rating, 19 reviews4 Bedroom Private Pool Paradise in Buenaventura
Villa in Playa Venao
4.98 out of 5 average rating, 61 reviewsCasa Aqua: Amazing beach front house - Playa Venao
Luxury mansion rentals
Home in Panamá
5.0 out of 5 average rating, 9 reviewsUnique 4 room house - direct access to the beach
Villa in Punta Chame
4.92 out of 5 average rating, 13 reviewsFREE NIGHT Amazing Beachfront Villa - Palm House
Apartment in Maria Chiquita
4.95 out of 5 average rating, 21 reviewsPenthouse in Playa Escondida 4 bedrooms
Villa in Bejuco
4.96 out of 5 average rating, 78 reviewsBeach house in Punta Chame, Villa frente al mar
Villa in Río Hato
4.91 out of 5 average rating, 22 reviewsSecluded Villa in Buenaventura Golf and Resort
Villa in Río Hato
4.92 out of 5 average rating, 73 reviews(Panama) Beach house with golf course.
Home in Anton Valley
5.0 out of 5 average rating, 25 reviewsLovely and Cousy house at El Valle
Hut in Cristóbal Island
4.89 out of 5 average rating, 72 reviews✨Exclusive✨Jungle Retreat on Bioluminescent Lagoon
Pet-friendly mansion rentals
Home in Río Hato
4.98 out of 5 average rating, 99 reviewsRenewed / Make yourself at Home / Enjoy
Condo in San Carlos District
4.97 out of 5 average rating, 38 reviewsPunta Caelo Beach Front View
Villa in Costa Esmeralda
4.97 out of 5 average rating, 71 reviews#1 Villa with pool, jacuzzi, pool table, ping pong.
Home in San José
5.0 out of 5 average rating, 21 reviewsαlkeyler| Luxury Mini Resort 12 PERS @Punta Barco
Villa in Bocas del Toro
5.0 out of 5 average rating, 56 reviewsCasa del Mar - eco aqua villa
Villa in Costa Esmeralda
5.0 out of 5 average rating, 15 reviewsSpectacular 600-meter oceanfront beach house
Home in Panamá
5.0 out of 5 average rating, 11 reviewsWonderful House with Terrace and Sea View
Home in Gamboa
4.86 out of 5 average rating, 88 reviewsBirdHouse@ Gamboa Panamá Canal
Destinations to explore
- Hotel rentals Panama
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