Hotel vacation rentals in Panama
Find and book unique hotel rentals on Airbnb
Top-rated hotel rentals in Panama
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama hotel rentals
Family-friendly hotel rentals
Hotel room in Playa Venao
4.7 out of 5 average rating, 20 reviewsEstrella Room - Quiet, budget friendly - queen bed
Nature lodge in Darién Province
4.67 out of 5 average rating, 18 reviewsLa Chunga
Private room in Isla Bastimentos
4.93 out of 5 average rating, 28 reviewsBeach Bungalow on Bastimentos w/ Meals & Transport
Hotel room in San Carlos
4.79 out of 5 average rating, 109 reviewsB) Beach, surf and Relax with King size bed
Private room in Tonosí
El Ranchito Family Room
Hotel room in Playa Morillo, Mariato
4.94 out of 5 average rating, 34 reviewsDouble room IXORA with partial ocean view balcony
Casa particular in Bocas del Toro
4.95 out of 5 average rating, 87 reviewsUrania House
Private room in Cébaco
4.57 out of 5 average rating, 14 reviewsIsland Lodge Retreat Cebaco Sunrise/Cebaco Island
Hotel rentals with a pool
Hotel room in PA
4.9 out of 5 average rating, 29 reviewsVilla Coco King Room
Hotel room in Panamá
4.95 out of 5 average rating, 37 reviewsVilla Royale
Private room in Panamá
4.84 out of 5 average rating, 19 reviewsRelax Room
Hotel room in Lagartero
4.75 out of 5 average rating, 12 reviewsCharming 1-Bedroom Beachfront Hotel With Pool
Hotel room in Playa Coronado
4.58 out of 5 average rating, 19 reviewsGolf luxury mango pool suite
Hotel room in Colón Island
4.92 out of 5 average rating, 24 reviewsOceanview Room 2
Private room in Cañas
5 out of 5 average rating, 8 reviewsStandard Suite
Hotel room in Bocas del Toro
5 out of 5 average rating, 5 reviewsDolphin Bay Hideaway- Caribbean Room
Hotel rentals with a patio
Hotel room in Coclé Province
5 out of 5 average rating, 6 reviews2-SUITE SUITE crowned luxuryclub
Private room in Alto Boquete
Cozy private room with bathroom in Alto Boquete
Casa particular in Río Hato
4.6 out of 5 average rating, 5 reviewsVilla en Playa Blanca Resort Río Hato
Hotel room in Bocas del Toro
New place to stayHotelito del Mar Quadruple Room
Hotel room in Panamá
Charming Studio w King Bed
Hotel room in Bocas del Toro
4.56 out of 5 average rating, 41 reviewsSeahorse A/C Mini Garden Cabin
Private room in Bocas del Toro
4.89 out of 5 average rating, 9 reviewsOHANA Ocean View SURF SPOT #3
Hotel room in Bocas del Toro
Boutique Skate + Surf Hotel | King Bed
Destinations to explore
- Rentals with pools Panama
- Beach house rentals Panama
- Rentals with a fire pit Panama
- Serviced apartment rentals Panama
- Ski-in/ski-out rentals Panama
- Beach condo rentals Panama
- Rentals with a fireplace Panama
- Treehouse rentals Panama
- Rentals with a sauna Panama
- Boutique hotel rentals Panama
- House rentals Panama
- Rentals with a home theater Panama
- Bed and breakfasts Panama
- Farmstay rentals Panama
- Rentals with breakfast Panama
- Smoking-friendly rentals Panama
- Chalet rentals Panama
- Monthly Rentals Panama
- Rentals with an EV charger Panama
- Hostel rentals Panama
- Mansion rentals Panama
- Private suite rentals Panama
- Apartment rentals Panama
- Vacation home rentals Panama
- Boat rentals Panama
- Island rentals Panama
- Rentals with a hot tub Panama
- Loft rentals Panama
- Condo rentals Panama
- Townhouse rentals Panama
- Bungalow rentals Panama
- Fitness-friendly rentals Panama
- Pet-friendly rentals Panama
- Beachfront rentals Panama
- Rentals with a kayak Panama
- Kid-friendly rentals Panama
- Rentals with an accessible height bed Panama
- Tiny house rentals Panama
- Family-friendly rentals Panama
- Cabin rentals Panama
- Rentals with outdoor seating Panama
- Rentals with a patio Panama
- Rentals with beach access Panama
- Guesthouse rentals Panama
- Rentals with a washer and dryer Panama
- Rentals with lake access Panama
- Villa rentals Panama
- Nature eco lodge rentals Panama
- Cottage rentals Panama
- Waterfront rentals Panama
- Hotel rentals Panama City
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom