House vacation rentals in Orangeburg County

Find and book unique houses on Airbnb

Top-rated house rentals in Orangeburg County

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Orangeburg

5 out of 5 average rating, 18 reviews

Theo's Place

Kick back and relax in this calm, stylish space. I'm happy to offer my 1st home as a host, providing all the amenities I've wanted as a guest in my years of successful stays on the AirBnB platform as a guest (laptop not included). My guest will find various comforts and additions to make their stay as comfortable as can be. I welcome your feedback. My home is available as a 1 Bedroom with a large Den, Living & Dining rooms, 2 Bathrooms, full Kitchen and Laundry room. All new appliances as well.

Guest favorite

Home in Orangeburg

4.89 out of 5 average rating, 19 reviews

Nene’s Cozy Corner

Time to get Cozy. Relax here with your family and friends at this peaceful place to stay. Or stay if in the area for work. Close to Edisto Memorial Gardens, 8 miles to South Carolina State University, 9 miles to Claflin University, a couple of minutes away from the drag strip, 11.5 miles from The Hillcrest Golf Club and close to many restaurants, stores and shopping centers. Come kickback and relax at “Nene’s Cozy Corner”. Extra parking in front and back yard for motorbikes, boats, cars and more

Guest favorite

Home in Olar

4.95 out of 5 average rating, 144 reviews

The Pond House at Salkehatchie Farms

The Pond House is a secluded getaway in the woods with double glass doors throughout the house so you can enjoy nature, even while you are inside. It sits at the end of the winding drive through dogwoods in the spring, green trees in summer and colored leaves in autumn. There is a small pond on the edge of the property. Outdoor patios are a wonderful place to breathe in the early morning air, watch a sunset, or grill. There is plenty of room for walks and the property is yours to explore.

Superhost

Home in Orangeburg

4.92 out of 5 average rating, 36 reviews

Charming Furnished Apartment

Fully furnished including full kitchen, linens, flat screen Roku TV, Wireless Internet, Living room, dining, kitchen, new front load washer and dryer, tiled bathroom, comfortable queen bed, 1 large bedroom, lots of light, fenced yard. Convenient Pet Notes: Pets have to be approved in advance of stay and pet fees will be charged Pets are welcome but there is a pet fee based on number of dogs and breed. Some breed are restricted by insurance company. Contact me before booking please.

Guest favorite

Home in Orangeburg

4.95 out of 5 average rating, 19 reviews

Ron's Siesta Airbnb

A beautifully renovated Cape Cod, reminiscent of the late 1940's is located near restaurants, groceries, and the universities; some of which are in walking distance. While located on a main thoroughfare, the home exudes a quiet and peaceful atmosphere. There are two bedrooms, bath, kitchen, eating and dinning area. A warn place to feel welcomed and at home. Universities: SCSU walk 18 min 1.0mil; Claflin University walk 15min. 0.8 mil; The Village Center walk: 3min 0.2mil.

Guest favorite

Home in Summerton

4.83 out of 5 average rating, 103 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

Guest favorite

Home in Denmark

4.93 out of 5 average rating, 101 reviews

Lowcountry river life

0ur river house sits on the banks of the South Edisto River, the longest free flowing black river in the U.S. This three bedroom, two bath house is on a high sloping lot with a boat shed, concrete boat landing and large dock overlooking the main river stream. This location offers a chance for adventures in fishing, canoeing, and or kayaking . Or you can simply relax on the dock or the screened- in back porch and enjoy nature and the wildlife.

Superhost

Home in Santee

4.69 out of 5 average rating, 67 reviews

Cozy 3 Bedroom Farmhouse

Relax with the whole family at this peaceful farmhouse. This country home is just minutes from the town of Santee and I-95 South. It is perfectly located less than 10 minutes from Lake Marion, so you can relax at the lake and retreat to a safe, quiet place for the night. The spacious yard has lots of room for your RV or boat, so bring all you need for the perfect trip. Experience the perfect “at home feeling” to make your stay like no other.

Guest favorite

Home in Summerton

4.97 out of 5 average rating, 135 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Gorgeous luxury log home directly on the big waters of Lake Marion with fishing pier/boat dock, brand new salt water pool, hot tub and much more! This custom home boasts 3 large bedrooms and a loft, two large bathrooms with double sinks, one with claw foot soaker tub and separate water closet. Huge screened in back porch for dining and entertainment with custom 12' outdoor bar. This home is 6 minutes from I-95.

Guest favorite

Home in Orangeburg

4.92 out of 5 average rating, 24 reviews

Garden City Getaway

Have fun with the whole family at this stylish place while creating memories and enjoying the amenities of home while you travel. This home is perfect for visiting your college student, taking in a game or if you’re in town for work. The neighborhood is very established, quiet and safe. Just minutes from S.C. State and Claflin.

Guest favorite

Home in Summerton

4.93 out of 5 average rating, 88 reviews

Quiet 3-Bedroom home mins from lake and golf.

Relax with the whole family at this peaceful place to stay. The home has 3 Bedrooms and 2 Full Baths. 2 Queen beds and 1 Trundle Bed. Located just mins from Lake Marion and Golf Courses. Fire pit out back for you to relax, enjoy and maybe roast some marshmallows.