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House vacation rentals in Mesa County

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Top-rated house rentals in Mesa County

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Home in Grand Junction

4.85 out of 5 average rating, 706 reviews

Happy Hippie House

Welcome to our beautiful, 1950 home known by our guests as the Happy Hippie House! Our home's interior has been updated, giving it a fresh, chic hippie vibe. The eclectic decor creates a light & airy interior. Come hang out on the front porch! Discover wineries, skiing, hiking, biking, kayaking & rafting. Minutes from CMU, hospitals, & a lovely downtown area. Free Wi-Fi & Roku w/Netflix. Electronic lock for easy late check-in. LGBT & 420 friendly (outside)! Earns 5 stars for convenient location.

Home in Orchard City

4.95 out of 5 average rating, 453 reviews

The Orchard House

**A devastating freeze in October 2020 killed all 400 of our sweet cherry trees and many of our peach trees. Sadly, our orchard is not the lush green jewel it once was. We are planting new cherry trees in the Spring of 2022. While the orchard views have changed, the Orchard House continues to offer a very comfortable place to rest and recharge. Come enjoy fresh air and quiet whether you are stopping through on a road trip or staying longer for local adventure. Fast WiFi for telecommuting!

Home in Paonia

4.92 out of 5 average rating, 675 reviews

Kale's Private & Romantic Cottage - King, Kitchen

Kale's Cottage features a kind size bed and is the epitome of unique and comfortable stays in Western Colorado. Our award-winning, pet-friendly Solargon boasts an elegant design, and is located just a half-mile walk away from the charming downtown of Paonia. The 374 sq ft space offers a fully stocked kitchen, seasonal wood stove, work/dining table & spacious private bathroom with shower. Whether for a special getaway, work, hiking, business or adventure, this is your perfect home away from home.

Home in Grand Junction

4.97 out of 5 average rating, 159 reviews

Resort-like Adobe At Colorado Monument!

This newly renovated adobe style home will make you feel like you’re in a resort with amazing views. Perfect for a family vacation, girls/guys trip, mountain biking trip, romantic getaway, wine tasting or just a weekend getaway this is the perfect home. Close to many outdoor activities including hiking, fishing, mountain biking, Paddle boarding/kayaking/tubing, golfing. Located 5 mins to Two Rivers and 25 mins to Palisade vineyards. We are offering the complete Colorado outdoor experience.

Home in Palisade

4.94 out of 5 average rating, 174 reviews

The Pali House A - Beautiful home on 10 acres

Thank you for considering a stay at our remodeled home, designed with luxury and comfort in mind. Enjoy the privacy of being on 10 acres with incredible views while being 3 min to wineries and 40 minutes to Powerhorn Ski Resort. House A is the upstairs unit of this two story ranch home. With a private entrance, living room, dining room, fully stocked kitchen, and incredible wrap around deck, this unit is a perfect retreat for a weekend away or work remote paradise. Your hosts, Joe & Trish

Home in Grand Junction

4.99 out of 5 average rating, 105 reviews

NEW Downtown Pet Friendly!Art on White Suite!

✨2 blocks to Main Street! Art on White Suite gives you an artistic, vintage, downtown experience with access to world-class mountain biking, winetasting, and much more! Our vintage home built in 1905, has quite a unique experience to offer. With love for our Community and Art, this eclectic space provides a relaxing, whimsical, light & airy stay. This 2 bedroom, one bath suite is attached to the main house- very private with a lovely back yard! We love this space and we hope you do too! ❤️

Home in Grand Junction

4.92 out of 5 average rating, 234 reviews

Colorful 2 bedroom pet friendly home

Make some memories at this unique and family-friendly place. Our home welcomes you and your pet/s to enjoy our 2 newly decorated bedrooms with blackout curtains, remodeled luxurious bathroom with 2 showerheads, full kitchen , laundry, pet door, dog run, back porch to sit and relax, and lovely backyard to enjoy. We encourage you to walk downtown, only 6 blocks away. The Colorado National Monument, regional airport, CMU, library, Science Center for kids, and bike trails are very close.

Home in Loma

5 out of 5 average rating, 488 reviews

Fruita/Loma Guest House at the Perfect Day Getaway

This newly constructed "Green" home is a mix of modern and country styles and will surely inspire you to enjoy all of the outdoor activities the Grand Valley has to offer. The Perfect Day Getaway house is located on a quaint farm within 8 minutes of world-class hiking, mountain and road bicycling, and river rafting. It is a great launching point for day trips to Moab and the Grand Mesa as well! It was built to maximize the southern exposure and views of the Colorado National Monument.

Home in Grand Junction

4.95 out of 5 average rating, 175 reviews

New, Clean & Cheerful Townhome

Enjoy your stay at this fully-stocked, clean and centrally located townhome in Grand Junction, CO! This newer, EnergyStar® rated home includes comfortable beds, 2 baths, one with large walk-in shower and the other with soaker tub. SmartTv and access to SlingTV with fast WiFi access. Full-size washer and dryer, and 1-car garage access features bike racks, workstation and tools for the mountain biking enthusiasts! Enjoy the covered patio with included BBQ grill and table seating area!

Home in Palisade

4.96 out of 5 average rating, 245 reviews

Galloway Ranch Palisade Colorado

Recent review: The best place we've ever stayed at, hands down! The location felt like a dead end road, yet close to everything. The yard had beautiful flower beds, not to mention the amazing view of Mt. Garfield! The house itself was very comfortable and had anything you can imagine in the kitchen, making a few at home dinners a breeze. Owners Note: One (1) dog 45 lbs max allowed unless an additional dog is approved in advance, please include # of people and # of dogs when booking.

Home in Grand Junction

4.86 out of 5 average rating, 228 reviews

Blue House - Dog, RV, and Trailer Friendly

The Blue House is located just south of downtown Grand Junction, adjacent to the Mesa County Fairgrounds and the Old Spanish Trail BLM area. It is also within bicycling distance of Downtown, Los Colonias, Riverfront Trail and Lunch Loop Trails. The house is a corner lot on a quiet dead-end street. Extensive outdoor spaces are the highlight here - perfect for dogs, aggressive children, and off-leash adults. RV/trailer parking with 30 amp service is also available.

Home in Palisade

4.96 out of 5 average rating, 217 reviews

Stay at The View House

Nestled in between peach orchards in beautiful East Orchard Mesa and right across from the Colorado River. Enjoy serenity at this beautiful home in a peaceful setting. Close to over 7 wineries off of the fruit and wine byway and enjoy the drive into quaint downtown Palisade. Pedestrian bridge to a great bike bath to Corn Lake or the Colorado River with an awesome launch for rafts, kayaks and paddle boards! This is a biker’s dream!

Vacation rentals for every style

Get the amount of space that is right for you

Cottages

Quaint homes, peaceful surroundings

Apartments

Convenient locations with everyday essentials

Cabins

Kick off your hiking boots at these rustic lodgings

Popular amenities for Mesa County house rentals

Free parking on premises

Air conditioning

House rentals with a pool

Home in Grand Junction

5 out of 5 average rating, 67 reviews

Pool, hot tub, views and close to everything

Home in Palisade

4.92 out of 5 average rating, 190 reviews

Peach Pad! hot or cool tub 2 bedrooms 2 bathrooms

Home in Grand Junction

Deluxe Dry Cabin- S201

Home in Grand Junction

4.29 out of 5 average rating, 7 reviews

The Whole Package Kind of Place!

Home in Grand Junction

The Beatrice Estate

Home in Palisade

4.82 out of 5 average rating, 57 reviews

Palisade Peach Orchard Farmhouse w/Pool & Spa 18+

Home in Clifton

4.91 out of 5 average rating, 74 reviews

The Honey Bee @ Palisade Legends

Home in Grand Junction

4.79 out of 5 average rating, 33 reviews

Adventure Home Base - 7 Blocks to Downtown!

Weekly house rentals

Home in Hotchkiss

4.95 out of 5 average rating, 164 reviews

The Moon House. Come mingle with the stars.

Home in Delta

4.99 out of 5 average rating, 141 reviews

Fully Stocked 3 BR HOME - Work & Play w/fast WiFi

Home in Fruita

4.98 out of 5 average rating, 177 reviews

The Centennial House ~ Your Adventure Starts Here!

Home in Grand Junction

4.97 out of 5 average rating, 115 reviews

NEW! Heart of Downtown: The Hill Oasis

Home in Grand Junction

4.95 out of 5 average rating, 154 reviews

Family friendly, quiet & comfy 3BR home North area

Home in Grand Junction

4.85 out of 5 average rating, 174 reviews

Monumental Memories

Home in Palisade

4.97 out of 5 average rating, 154 reviews

Downtown Palisade Charmer

Home in Grand Junction

4.97 out of 5 average rating, 154 reviews

The Downtown Farmhouse

Private house rentals

Home in Palisade

4.98 out of 5 average rating, 98 reviews

Peach Chalet, views, quiet, 5 min to downtown

Home in Delta

4.9 out of 5 average rating, 49 reviews

Thunder Mountain Vista-Captivating and Memorable

Home in Palisade

4.95 out of 5 average rating, 66 reviews

Rapid Creek Retreat

Home in Palisade

5 out of 5 average rating, 77 reviews

Love Orchard

Home in Grand Junction

4.85 out of 5 average rating, 65 reviews

Serene Riverwalk Retreat

Home in Mesa

4.93 out of 5 average rating, 46 reviews

Mesa Creek Cottage

Home in Loma

4.98 out of 5 average rating, 53 reviews

Horsethief Hideout |Hot Tub, Firepit, Grill, Views

Home in Fruita

4.89 out of 5 average rating, 151 reviews

Clean, Comfy, Best Patio in Fruita - dog friendly!

Destinations to explore