Guesthouse vacation rentals in Lexington County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Lexington County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Columbia

4.89 out of 5 average rating, 863 reviews

Tiny Guest House secluded USC-Vista-Capitol-Dwntwn

Welcome to our tiny guest cottage hidden in the heart of the city. It's within blocks of restaurants, coffee shops, an art movie house, and a lovely river walk. The Lace House/Governor’s Mansion, business district & UofSC are a short walk or bike ride away. At the rear of our home, it’s private, secure & quiet. A partition & movable screen separate the bathroom area. There’s a smart tv, small fridge, microwave, coffeemaker & work-table.24 hr self check-in.HOUSEHOLD VACCINATED STRO-000579-03-2024

Guest favorite

Guesthouse in Columbia

4.88 out of 5 average rating, 152 reviews

Bubba’s Bungalow

Located next door to “Bubba’s Tranquility Treehouse” this Beautifully appointed, fully furnished Shandon Cottage Awaits you. Same block as Anytime Fitness. Walking distance to Earthfare, Publix,Social Pig,All the Bars & Boutiques of the Devine Corridor, CVS, 5points & USC. 5 minutes from Williams Brice Stadium,Colonial Life Arena, Convention Center, Whole Foods, Downtown, I-77, I-26 & The Vista .Enjoy all of the prestige of staying in Columbia’s oldest community, While relaxing with amenities

Guest favorite

Guesthouse in Columbia

4.91 out of 5 average rating, 182 reviews

Vintage Rosewood Carriage House

Our cozy guest house has been completely remodeled and is ready for action! Lots of natural light, custom woodwork, and salvaged items make this space extra unique. The main floor has a kitchenette, living area with a pull out couch, and full bathroom. Head up to the loft to relax in the queen bed. Our place is in the heart of Rosewood where you can walk or bike easily to the grocery store, several parks and bars/restaurants. Downtown Columbia and USC's campus are both less than 3 miles away.

Guest favorite

Guesthouse in Columbia

4.99 out of 5 average rating, 159 reviews

❃ The Rosewood Loft ❃ Desk, Kitchen & Laundry

STRO-004413-11-2023 Wonderfully comfortable, quiet, clean, and spacious loft in the heart of Rosewood, one of Columbia's most convenient, safe, and popular neighborhoods! ★ 8-minute drive to Founders Park, home of USC Baseball. ★ Minutes from USC campus, Fort Jackson and downtown Columbia. ★ 6 min walk to groceries (Publix), several restaurants and a brewery. ★ Quiet and walkable neighborhood. ★ Secure, off-street, 1-car parking behind a 6' fence. ★ Seamless check-in with keypad lock.

Guest favorite

Guesthouse in Lexington

4.97 out of 5 average rating, 158 reviews

Lake front Lake Murray in the Heart of Lexington

Walk out onto Lake Murray in the heart of Lexington! From sunrise to sunset this home is perfect for that relaxing get away; a private beach is steps from your door, a dock to fish from, boat ramp to launch your lake toys, quite cove with beautiful wild life! As the owners we live in the upstairs of the home (completely securely separated) and are available if you need anything! We enjoy sharing this beautiful home with others! Please note the beach, dock and lake are shared spaces.

Guest favorite

Guesthouse in Lexington

5 out of 5 average rating, 239 reviews

Modern Cottage in Peaceful and Central Location

Nestled on a secluded property, overlooking beautiful land, our peaceful guest house is perfect for a relaxing stay away from home. Ideally located off I-20, this private cottage is less than 10 miles from downtown Columbia, Riverbanks Zoo & the airport and it is just minutes from Lake Murray, restaurants, coffee & shopping. We have sought to make your stay relaxing, quiet & secure. Enjoy this cottage all to yourself with a private entrance and off-street parking.

Guest favorite

Guesthouse in Lexington

4.94 out of 5 average rating, 261 reviews

Come Pause and Relax!

Looking to relax and unwind in a little home away from home? Our newly renovated guest house is the ideal place for total comfort. Nestled behind our home awaits your quiet “cottage in the trees.” Here you’ll find a full kitchen for cooking and a spacious living area for relaxing. Heavenly sleep awaits you in this oh-so-cozy bed with bamboo sheets. A stylish bath gives you what you need to refresh. Soak up fresh air in a backyard oasis. Destination relaxation!

Guest favorite

Guesthouse in Columbia

4.89 out of 5 average rating, 385 reviews

Cozy retreat near Williams Brice/Ft. Jackson/UofSC

Follow us @southshandonstreet! – 900 sq. ft. charming guesthouse in the heart of historic Columbia. – Fully furnished with modern/boho decor. – 2-3 miles from Ft. Jackson; 2 miles from UofSC; walking distance from Williams-Brice Stadium – Walking distance to the famous Rosewood Dairy Bar where you can go for quick fried snack or soft serve ice cream. Restaurants, grocery store, and bars also located within walking distance.

Guest favorite

Guesthouse in Columbia

4.78 out of 5 average rating, 379 reviews

Writer's haven in private guesthouse.

Cozy guesthouse makes an ideal writer's retreat! Located in an attractive, quiet neighborhood close to dining and shopping. On-street parking on non-busy side street. Hosts will work with you on creating fun rewards for writing goals. Space has a microwave, refrigerator, coffee maker, and electric kettle, and hosts will provide coffee, tea, wine, bottled water, and snacks, as well as continental breakfast.

Guest favorite

Guesthouse in Columbia

4.92 out of 5 average rating, 124 reviews

Brand New Studio Guest House with Full Kitchen.

Enjoy a stylish experience at this centrally-located house. Within a one mile radius of downtown Columbia, University of South Carolina, Benedict College stadium, Prism Health Richland Hospital, Prism Health Baptist Hospital and MUSC medical center. Fort Jackson is less than 10 minutes away! Certified service animals only are welcomed with a fee. There is also a fee for guest under the age of 25.

Guest favorite

Guesthouse in Columbia

4.9 out of 5 average rating, 144 reviews

Quaint Haven: Your Cozy Retreat

Welcome to Quaint Haven, your ultimate cozy retreat! Our charming Airbnb offers a tranquil and intimate getaway nestled in a picturesque setting. Immerse yourself in the warmth and comfort of our thoughtfully designed space, featuring a minimalist yet stylish interior. A cozy living area, and a compact kitchenette, our Quaint Haven provides everything you need for a relaxing stay.

Guest favorite

Guesthouse in West Columbia

4.95 out of 5 average rating, 647 reviews

Carriage House: Studio Bed & Bath - Pool & Hot Tub

Minutes from Lexington Medical Center, USC, Lake Murray, River Bank Zoo, Downtown Columbia and CAE Airport! Secluded stand alone Garage Carriage House w/Upstairs private studio bedroom with a full size bath on main floor. Enjoy your private patio, garden, grill, and so much more! Guest are welcome to enjoy our Beautiful Salt-water Pool with Gorgeous Night Lighting.