![](https://a0.muscache.com/im/pictures/1ff6d909-5ba6-42f3-9d2c-fa2327780936.jpg)
Guesthouse vacation rentals in Colleton County
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Colleton County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Colleton County guesthouse rentals
Family-friendly guest house rentals
![](https://a0.muscache.com/im/pictures/miso/Hosting-715448/original/0ac8fcdb-1000-4ca2-ba1b-4ee445d2264e.jpeg?im_w=720)
Guesthouse in Beaufort
4.94 out of 5 average rating, 233 reviewsCozy private guest house
![](https://a0.muscache.com/im/pictures/e00345f9-d2ce-4cc7-97f5-4b8830fe869e.jpg?im_w=720)
Guesthouse in Beaufort
4.94 out of 5 average rating, 402 reviewsMeridian Rd. Guest House Walk to Restaurants/Parks
![](https://a0.muscache.com/im/pictures/miso/Hosting-18720189/original/1d6c1605-3e70-41fb-bf06-93cdfb54b532.jpeg?im_w=720)
Guesthouse in Ridgeville
4.82 out of 5 average rating, 216 reviewsPond House Bungalow at Natural Gathering Grounds
![](https://a0.muscache.com/im/pictures/fc9b53a3-1e30-4865-bc1a-892d105b1643.jpg?im_w=720)
Guesthouse in Beaufort
4.98 out of 5 average rating, 371 reviewsThe Wren Guest House
Guest house rentals with a patio
![](https://a0.muscache.com/im/pictures/miso/Hosting-586749349172385415/original/e649f796-1227-4293-b1d0-bb97e6d180f6.jpeg?im_w=720)
Guesthouse in Beaufort
4.66 out of 5 average rating, 44 reviewsWaterfront! Guest House!
![](https://a0.muscache.com/im/pictures/miso/Hosting-1130720270401225815/original/82187c28-d652-424a-98e2-c51667eeb747.jpeg?im_w=720)
Guesthouse in Hollywood
5 out of 5 average rating, 5 reviewsCharming Farm Stay in Hollywood
![](https://a0.muscache.com/im/pictures/miso/Hosting-608108393119382617/original/7b4ee964-812e-4b66-ae25-3becaa6b5288.jpeg?im_w=720)
Guesthouse in Seabrook
5 out of 5 average rating, 49 reviewsAdorable guesthouse outside Beaufort
![](https://a0.muscache.com/im/pictures/7f4f5ba9-2d29-4983-9e14-6ffd882679e2.jpg?im_w=720)
Guesthouse in Ridgeville
4.86 out of 5 average rating, 37 reviewsCute Frog
![](https://a0.muscache.com/im/pictures/miso/Hosting-712130267551373767/original/a4075f5b-902e-4e6b-9902-30485697fa30.jpeg?im_w=720)
Guesthouse in Summerville
4.98 out of 5 average rating, 56 reviewsHearts & Dreams Peaceful Family Retreat w/ pool
![](https://a0.muscache.com/im/pictures/miso/Hosting-639753834626030778/original/5811e6d4-70e1-4d6d-9f66-43c21aa522e7.jpeg?im_w=720)
Guesthouse in Saint George
4.97 out of 5 average rating, 64 reviewsSimmons Sweet Suite
Guest house rentals with a washer and dryer
![](https://a0.muscache.com/im/pictures/miso/Hosting-1101506767594819691/original/2dfe7138-39f7-44ad-8395-6db0f4764fe0.jpeg?im_w=720)
Guesthouse in Hollywood
5 out of 5 average rating, 6 reviewsCharming Country Retreat
![](https://a0.muscache.com/im/pictures/miso/Hosting-1162691011024045906/original/c5851a52-26fd-4189-ae73-bc81cb8bc378.jpeg?im_w=720)
Guesthouse in Summerville
5 out of 5 average rating, 6 reviewsDetached Studio Cottage
![](https://a0.muscache.com/im/pictures/22588b6d-bf0e-4667-b421-e0083fb18099.jpg?im_w=720)
Guesthouse in Beaufort
4.88 out of 5 average rating, 113 reviewsParadise Blue, bright, airy carriage house in town
![](https://a0.muscache.com/im/pictures/fc9b53a3-1e30-4865-bc1a-892d105b1643.jpg?im_w=720)
Guesthouse in Beaufort
4.98 out of 5 average rating, 371 reviewsThe Wren Guest House
![](https://a0.muscache.com/im/pictures/f16cb3fa-3e37-4e0e-b413-ec53cacb4b9e.jpg?im_w=720)
Guesthouse in Beaufort
4.98 out of 5 average rating, 216 reviewsBuddy's Cottage near everything in Beaufort, SC
![](https://a0.muscache.com/im/pictures/346027fd-298c-4c8f-9c1b-ccfcd0623781.jpg?im_w=720)
Guesthouse in Beaufort
4.64 out of 5 average rating, 22 reviewsQuaint 1/1 Guest House + Shared Property & Yard
![](https://a0.muscache.com/im/pictures/miso/Hosting-53750268/original/26c4f3ec-bf75-4214-9677-170ac3f88b45.jpeg?im_w=720)
Guesthouse in Summerville
4.88 out of 5 average rating, 32 reviews1 Bed Detached Guest House, No Smokers, No Animals
![](https://a0.muscache.com/im/pictures/miso/Hosting-639753834626030778/original/5811e6d4-70e1-4d6d-9f66-43c21aa522e7.jpeg?im_w=720)
Guesthouse in Saint George
4.97 out of 5 average rating, 64 reviewsSimmons Sweet Suite
Destinations to explore
- House rentals United States
- Guesthouse rentals United States
- Guesthouse rentals Charleston
- House rentals Charleston
- House rentals Savannah
- Guesthouse rentals Savannah
- House rentals Hilton Head Island
- Guesthouse rentals South Carolina
- House rentals South Carolina
- Rentals with a fireplace Colleton County
- Rentals with breakfast Colleton County
- Rentals with outdoor seating Colleton County
- House rentals Colleton County
- Rentals with a washer and dryer Colleton County
- Apartment rentals Colleton County
- Beachfront rentals Colleton County
- Rentals with beach access Colleton County
- Rentals with a patio Colleton County
- Family-friendly rentals Colleton County
- Rentals with pools Colleton County
- Fitness-friendly rentals Colleton County
- Rentals with a hot tub Colleton County
- Condo rentals Colleton County
- Pet-friendly rentals Colleton County
- Rentals with lake access Colleton County
- Kid-friendly rentals Colleton County
- Waterfront rentals Colleton County
- Rentals with a kayak Colleton County
- Rentals with a fire pit Colleton County
- Monthly Rentals Colleton County
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom