Guesthouse vacation rentals in Anderson County

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Top-rated guesthouse rentals in Anderson County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Abbeville

4.97 out of 5 average rating, 316 reviews

Scenic Loft in the Woods

Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!

Guest favorite

Guesthouse in Six Mile

4.99 out of 5 average rating, 138 reviews

Your Charming Country Cottage

Whether you need a country getaway or a place to lay your head after a football game, our cottage in the foothills of upstate SC is the perfect spot for both. You’ll find us tucked away just outside the quaint little town of Six Mile, 10 miles north of Clemson University and in close proximity to 3 of the upstate's favorite lakes: Lake Keowee, Lake Jocassee and Lake Hartwell. Here you’ll enjoy the serenity of country life without feeling “too far out" or away from all the upstate has to offer.

Guest favorite

Guesthouse in Honea Path

4.97 out of 5 average rating, 31 reviews

The Honey Flat

Welcome to this newly built flat with a loft in the town of Honea Path, SC. Providing the traveler with a cozy, fun place to sleep for up to 5 people. Perfect place for small family or individual travelers. Centrally located you will find a clean and comfortable atmosphere. Just 15 minutes from Erskine College and 25 minutes from Anderson. Come stay in our fully furnished guesthouse with unique decor and fun pops of color! We look forward to hosting you in our small town with a big heart.

Superhost

Guesthouse in Anderson

4.86 out of 5 average rating, 183 reviews

Farmhouse by the lake - Private guest house

1,200 square foot apartment over a quiet barn on a cul-de-sac of a lake community. Near I-85, T. Ed Garrison Livestock Arena, downtown Pendleton, Clemson, and Lake Hartwell. Perfect for Clemson football games, horse/livestock shows or trail riding at Garrison Arena, lay over with horse, graduation, visiting your college student, fishing tournaments, or vacationing near Lake Hartwell. A private guest house overlooking sheep pastures and woods. Accessed by flight of stairs.

Guest favorite

Guesthouse in Pendleton

4.89 out of 5 average rating, 251 reviews

La Bella Farm

Do you want to be close to Clemson(11 miles), Anderson(9 miles) OR Greenville(20miles)! Do you want to just get away from all of the noise and busy life. Then you have found your spot! This is a great detached garage apartment. Settled in the quiet country side of Pendleton SC. 1 bedroom&1 bathroom with an additional sofa bed&blow up mattress. Great view of nothing but beautiful land from the kitchen window yet minutes away from Death Valley,restaurants,shopping and 85.

Guest favorite

Guesthouse in Anderson

4.93 out of 5 average rating, 246 reviews

Be Our Guest

Relax & enjoy the peace & tranquility of the lake in our charming second-floor guesthouse! Convenient location for families, fishermen & Clemson fans. Two bedrooms, full kitchen, spacious single bath, high ceilings, ceiling fans, fireplace & open floor plan in private unit. Fire pit & ample off-street parking for multiple boats & trailers. Close to Anderson & Clemson, less than 1 mile to boat launch. SMOKING PERMITTED OUTDOORS, NO PETS. Please do not sleep on the sofa.

Guest favorite

Guesthouse in Abbeville

4.98 out of 5 average rating, 55 reviews

The Parlor Two

Welcome to the country and an actual renovated milking Parlor! You'll find our place is ideal for relaxing, whether it's inside or siting on the porch, soaking in the beauty of a sunset or watching cows, donkeys, and horses on our working farm! We welcome long term guests and offer weekly and monthly discounts. We are less than 10 min to Abbeville, 12 min to Erskine College and Due West, & 17 min. to Diamond Hill Mine. NO PETS ALLOWED to better serve our guests!

Guest favorite

Guesthouse in Donalds

4.99 out of 5 average rating, 358 reviews

Home on the farm

aprox. 4 miles to Erskine College and aprox. 15 miles to Greenwood sc. You’ll love the farm setting, good for couples, solo adventurers, business travelers, families (with kids), and furry friends (pets).we are aprox. 11 miles from Abbeville SC birth place of the confederacy. aprox. 60 miles to Augusta GA the masters golf tour. aprox. 40 miles to CLEMSON U. The Diamond Hill Mine in Abbeville is about 17 miles from here.

Guest favorite

Guesthouse in Pelzer

4.95 out of 5 average rating, 42 reviews

Quaint guest cottage in Upstate

This special property is near Greenville, Anderson, Clemson and more. Located just 3.6 miles from I-85 on Main Street West Pelzer, you can go any direction making this the perfect home base for exploring the Upstate. This charming cottage combines comfort, city and country. We strive to "think of everything" so your stay is fabulous. And you will love coming "home" to The Canning House after all your daily adventures!

Guest favorite

Guesthouse in Hartwell

4.97 out of 5 average rating, 73 reviews

One bedroom lake front apartment with free parking

Relax in a cozy apartment on Lake Hartwell. The apartment is located in a secluded peaceful, cove near downtown Hartwell and is in close proximity to hiking and numerous outdoor activities in the hill country of Georgia and South Carolina. The apartment sleeps 2 comfortably and is fully equipment with a kitchen and a private laundry facility.

Guest favorite

Guesthouse in Six Mile

4.9 out of 5 average rating, 110 reviews

Camper at Hickory Lodge and Guesthouse

Simple, relaxed atmosphere on a nicely wooded property less than 10 minutes from public launch and Sunset Marina on Lake Keowee. Boat parking is available. Only 19 minutes from Memorial Stadium, 15 minutes from Seneca, Pickens, Clemson. LESS THAN A MILE FROM DUKE OCONEE PLANT Need another bedroom? Please see our other listings