Guesthouse vacation rentals in Seminole County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Seminole County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Sanford

4.96 out of 5 average rating, 94 reviews

Little Hidden Cottage

Located in Sanford Florida, our Hidden Little Cottage is a private guest house with its own entrance, features a full kitchen and bath room, queen size bed, full size pull out couch and twin size travel bed, and provides flexible self check-in. We are located 7 minutes from the Sanford Airport and Boombah Sports Complex, 10 minutes to Downtown Sanford, I –4 & 4–17. We are also central to many Central Florida attractions such as Natural Springs, Sandy Beaches, Theme Parks and Historic Districts.

Guest favorite

Guesthouse in Sanford

4.95 out of 5 average rating, 248 reviews

Palmetto Pool Retreat

The Palmetto Pool Retreat offers complete privacy - detached studio cottage, with a pull-down Queen Murphy bed. * Kitchen - refrigerator, stove, cookware, Keurig , microwave, toaster, dishes and utensils. * Studio Living area - Queen size Murphy Bed, Roku TV, WiFi Internet, AC/Heater; Closet, Iron. Please don’t put AC lower than 72. * Private Bathroom - shower, hairdryer. *Outdoors - Solar heated pool(not propane heated) with private sitting area with 2 Fire pits Gas & Wood; BBQ Gas

Guest favorite

Guesthouse in Lake Mary

5 out of 5 average rating, 17 reviews

Nature Unique lake view Tiny Guest studio

Tiny Guest house studio with separate entrance for privacy and amazing Lake view. Unlimited rental of 2 Blue kayaks included during stay!! Walking distace from windixie supermarket, downtown lake Mary, restaurants, shopping centers, entertainment and dunking Donuts. Common areas outside studio are shared. Property is at lake Mary across Country club, close to Sanford, Boombah Sports, Orlando Fl. 30 min to Daytona Beach. Near Wekiva springs. To go to Disney, easy access to I-4 and 4-17.

Guest favorite

Guesthouse in Oviedo

4.96 out of 5 average rating, 264 reviews

Gated Luxury Country Home on Private 35 Acres

Unique 800 sq. ft standalone guesthouse on 35 private wooded acres. Relax in peace and quiet either outside with the beautiful scenery or inside with our professional GoldenWest 9' pool table. Fully furnished backyard patio with grill and smoker, firepit for cold evenings, kerosene lamps for ambiance, and lounge furniture for finishing that book you've been putting off. Conveniently located minutes away from 417, you are within reach of all that Orlando has to offer! NO CLEANING FEES!

Guest favorite

Guesthouse in Lake Mary

4.99 out of 5 average rating, 97 reviews

Sunset Cottage in Lake Mary, Florida

Located on beautiful Lake Mary, this completely renovated studio sized guest house offers beautiful sunsets over the lake from a private patio. A comfortable queen bed, stylish sitting area and fully stocked kitchenette make for a wonderful stay in the Lake Mary- Sanford area. Minutes from the Sanford airport, close to the Sunrail station and 45 minutes to either Disney World or the beach. Our guest cottage is a perfect place to visit. Please note: The cottage is lakeview only.

Guest favorite

Guesthouse in Sanford

4.94 out of 5 average rating, 96 reviews

Suite Retreat

Avoid blah hotels with high prices and stay in this luxe new apartment suite! It’s a perfect retreat in Central Florida. Located a short drive to activities, restaurants, & shops in Lake Mary or downtown Sanford - 45-55 min to Orlando theme parks or the beaches of New Smyrna. Ideal for a couple’s retreat or a getaway for one. Guests use office space designed for comfort & productivity. A cozy chair begs readers to curl up and read. The outdoor canopy hosts breakfast with birdsong!

Guest favorite

Guesthouse in Sanford

5 out of 5 average rating, 18 reviews

The Sanford Foodie Guest House

Indulge in the flavors of Sanford while staying at our new exclusive foodie guest house with brand new ICE COLD Air! Welcome to our private guest house in the heart of downtown Sanford, FL. Only 6 minutes from Sanford International Airport, and only 13 minutes from Central Florida zoo! This new space includes a queen size bed and a love seat couch that pulls out to a bed. Amenities include coffee maker, microwave, toaster, mini fridge, and private outdoor seating area.

Guest favorite

Guesthouse in Longwood

4.9 out of 5 average rating, 41 reviews

Cozy and Modern Studio suite in Longwood

This is a lovely and quite guest suite, you will have a fully stocked and private kitchen and your own bathroom in a lovely guest house (food not included). Easy parking with a private entrance. The room is equipped with a queen sized bed, smart TV and Wi-Fi. 5 minute drive from restaurants and Altamonte Mall. Easy access to I-4, 20 minutes from Orlando Downtown and 40 minutes from Orlando beaches and Disney Attractions.

Guest favorite

Guesthouse in Deltona

5 out of 5 average rating, 27 reviews

Guest house on the lake

Welcome to our Lakeside retreat! Nestled along the tranquil shores of a picturesque lake, our Airbnb offers a serene escape from the hustle and bustle. Enjoy breath-taking views from the private balcony and unwind in the cozy living space. This charming getaway is a perfect blend of modern comfort and natural beauty, promising a rejuvenating experience for every guest. Trailer and garaged motorcycle parking is available.

Guest favorite

Guesthouse in Maitland

4.87 out of 5 average rating, 386 reviews

Chez Bienvenu

Close proximity to Park Avenue in Winter Park! Sunny and Adorable Vintage Guest House ...entire spacious guest house; with private entrance and driveway* Just a couple of blocks off Park Avenue to enjoy Shopping! Cafes! Museums! Nestled in quiet family community* •Smart TV •Stackable washer and dryer included in the unit. •Grill, Beach Chairs, Fishing Poles available •750 square feet of living space

Guest favorite

Guesthouse in Maitland

4.99 out of 5 average rating, 136 reviews

Private 1-bd Mid-Century Guesthouse

Welcome to our tranquil & private 1-bd Mid-Century Modern Guesthouse. The space has a separate entrance and keyless access. Full kitchen, living room, bedroom and bathroom. Centrally located in Florida, our guesthouse offers easy access to the surrounding areas. Lots of museums, nature walks, parks & fantastic places to eat. Book now & experience the love & care we have put into our property!

Guest favorite

Guesthouse in Sanford

4.94 out of 5 average rating, 213 reviews

Private Courtyard Cottage on Canal

This is a small guest studio detached from the main house with its own private entrance. There is a kitchenette with a full size fridge, microwave, sink, air fryer and coffee maker. Most importantly there is an EXTREMELY comfortable king sized bed, TV and wifi. 5 minutes to Lake Mary Sunrail, quick access to historic downtown sanford, 20 min to downtown Orlando, 40 min to New Smyrna Beach.