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House vacation rentals in Santa Cruz Department
Find and book unique houses on Airbnb
Top-rated house rentals in Santa Cruz Department
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Santa Cruz Department house rentals
House rentals with a pool
![](https://a0.muscache.com/im/pictures/hosting/Hosting-1127577555191836416/original/4a646dc7-1030-4a4c-abfb-b53d2eee283e.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
5 out of 5 average rating, 5 reviewsVacation house with swimming pool
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Home in Santa Cruz de la Sierra
4.79 out of 5 average rating, 34 reviewsBeach House in Santa Cruz
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Home in Santa Cruz de la Sierra
4.69 out of 5 average rating, 16 reviews@Airbnb The House Of Don Lucho
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Home in Santa Cruz de la Sierra
5 out of 5 average rating, 3 reviewsIdeal work or studio and long stay
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Home in Santa Cruz de la Sierra
4.88 out of 5 average rating, 8 reviewsBeautiful house in private cond.
![](https://a0.muscache.com/im/pictures/miso/Hosting-642631730711594929/original/ba615e4d-6a67-4174-81e3-382923a2b017.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
5 out of 5 average rating, 14 reviewsCozy family home in private condo
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Home in Santa Cruz de la Sierra
4.95 out of 5 average rating, 20 reviewsCAPTIVATING HOUSE IN PRIVATE CLUB
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Home in Buena Vista
5 out of 5 average rating, 5 reviewsCasa Pueblo
Weekly house rentals
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Home in Camiri
4.33 out of 5 average rating, 3 reviewsHeavenly Corner
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Home in Santa Cruz de la Sierra
4.91 out of 5 average rating, 11 reviewsLuxurious house in the heart of the city.
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Home in Santa Cruz de la Sierra
5 out of 5 average rating, 5 reviewsCharming w/balcony facing park. Equipetrol 3D
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Home in Santa Cruz de la Sierra
5 out of 5 average rating, 6 reviewsComplete Family Home!
![](https://a0.muscache.com/im/pictures/miso/Hosting-52705966/original/8ca90304-6910-4708-9f71-ce63ec2e495c.jpeg?im_w=720)
Home in Samaipata
4.9 out of 5 average rating, 10 reviewsCABANA PICAFLOR
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Home in Santa Cruz de la Sierra
4.63 out of 5 average rating, 8 reviewsComfortable premium house in Private Condominium
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Home in Santa Cruz de la Sierra
4.75 out of 5 average rating, 4 reviewsBeautiful downtown room
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Home in Samaipata
4.62 out of 5 average rating, 26 reviewsLa Calata
Private house rentals
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Home in Santa Cruz de la Sierra
4.75 out of 5 average rating, 4 reviewsBeautiful Cabin in Samaipata
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Home in Mairana
4.91 out of 5 average rating, 11 reviewsLa Perla de los Valles. Casa Rustica. Rustic House
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Home in Santa Cruz de la Sierra
4.75 out of 5 average rating, 4 reviewsLinda Casa en Condominio Fontana Family Club
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Home in Santa Cruz de la Sierra
4.67 out of 5 average rating, 3 reviewsComfortable and pleasant house within the 4th ring
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Home in Santa Cruz de la Sierra
4.86 out of 5 average rating, 7 reviewsLA FELIPE. Home to enjoy.
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Home in Santa Cruz de la Sierra
New place to stayCasita Sirari
![](https://a0.muscache.com/im/pictures/hosting/Hosting-1183458048236473959/original/b30bc959-fc82-4b18-8f37-e817c4ddec3d.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
New place to stayFamily Home in Exclusive condo with Pools, Gym
![](https://a0.muscache.com/im/pictures/hosting/Hosting-1185620496913922818/original/46ea11ca-3c63-4a4a-abc1-68242efbd3d8.jpeg?im_w=720)
Home in Santa Cruz de la Sierra
New place to stayfamily and central luxury home
Destinations to explore
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