Guesthouse vacation rentals in Mesa

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Mesa

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in Paradise Valley

4.99 out of 5 average rating, 205 reviews

Scottsdale/PV Huge Guest House + Basketball Court

Spacious, private, & fully equipped. This 2 bedroom/2 bathroom luxury guest house sits on an acre in Scottsdale/PV & shares no walls with neighbors. Amenities include a steam shower, a basketball court, fast internet, 3 TVs, BBQ, washer/dryer, walk-in closet, split floor plan, & a full kitchen. No checkout chores! 2 beds, 2 sofas, & 2 fold out beds provide sleeping space for 8+. Elevate your travel experience in AZ’s premier 85253 zip code where I’m nearby & available 24/7 to address your needs.

Guest favorite

Guesthouse in Camelback East

4.8 out of 5 average rating, 227 reviews

Uptown Guest House

Comfortable and Spacious! Two blocks from Central Phoenix's Restaurant Row on 7th Street. PLEASE NOTE: There is an additional fee of $30 for additional guests. Comfortable, friendly, modern space with southwestern accents and includes use of pool in the Uptown Phoenix area. Within 5 minutes walking distance to a large park, pubs and many terrific restaurants. Great for singles, couples, a family of up to 4 or business travelers. A "must see" to understand the comfortable home-like atmosphere.

Guest favorite

Guesthouse in Scottsdale

4.97 out of 5 average rating, 100 reviews

Entire Private Guest House with King Master

•Location, Location, Location! Extremely safe/social neighborhood just minutes from Oldtown! 5- minute drive by car and 10 minutes by E-scooters! •Bordered by lush greenery, your private backyard/covered patio is a perfect place to enjoy the outdoors •Recently built in 2022 with luxury, comfort, and entertainment in mind ~ you'll love the vibe of your private small backyard and small yet spacious 520sqft space. This guest house has its own private, yet beautiful entrance TPT 21476951 AZ 2026023

Guest favorite

Guesthouse in Tempe

4.92 out of 5 average rating, 306 reviews

Unique urban habitat near ASU/downtown Tempe

Historic University Heights neighborhood is the location of this unique guesthouse adjacent to the host's home with it's own separate entry patio & parking. Short walk to Four Peaks brewery and Infusion Coffee. Sunny's Diner just 1/2 mile. Nearby grocers are Safeway, Trader Joe's, Whole Foods, Target.. Tempe Marketplace mall is a mile away. Free city shuttle and light rail train (goes thru Sky Harbor airport) are a four minute walk away. Close to 202,101 & 60 freeways. ASU is less than a mile.

Guest favorite

Guesthouse in Alhambra

4.98 out of 5 average rating, 132 reviews

Guest House in Historic Phoenix

Our guest house has many features our guests have enjoyed. Please look at the photos and read the reviews! I love being an Airbnb host and will do my best to make your trip great! Along with everything you'd expect, there is also a steam sauna, a private tennis court and a lush yard with green grass and fruitful citrus trees. We have a great central location in a quiet neighborhood. Finally, and it's a shame that I even have to note this, there are no crazy rules or exorbitant cleaning fees.

Superhost

Guesthouse in Camelback East

4.8 out of 5 average rating, 141 reviews

Adobe Style Family Guest House & Spacious Lawn

Welcome to our family Guest House! We have lots of outdoor space with an outside grill with bread oven and back patio. The house is two bedrooms, with a full kitchen, wifi, heat/AC, and off-street parking. Being just 0.3 miles off the AZ-51 freeway gives us seclusion in a safe and peaceful neighborhood alongside easy access to the rest of the Phoenix metro. This includes great hikes, the Botanical Garden, Zoo, Stadiums and great restaurants. Under 12 min to either the airport or Scottsdale.

Guest favorite

Guesthouse in Encanto

4.92 out of 5 average rating, 136 reviews

The Whittier Cottage, a cozy guesthouse in Phoenix

Unpack and relax in a newly renovated guesthouse filled with the warmth of an English-style cottage, in the heart of a desert city, downtown Phoenix (minutes from the airport). This charming guesthouse located in the Coronado District is a perfect place to call home for your next adventure, business trip, or romantic getaway with a ton of great and unique amenities, including an above-ground pool. Enjoy outdoor dining, your personal patio, the outdoor fit pit or cozy up inside with a movie.

Guest favorite

Guesthouse in Central City

4.89 out of 5 average rating, 141 reviews

Guest house in historic downtown

My cool and comfortable guest house is the ideal location for your visit to the Valley of the Sun! Located just minutes from the airport, the centrally located 400 square foot home has a full kitchen, flat screen tv, Bose sound dock, internet and private patio. The house is minutes from dozens of great downtown restaurants and bars. Going to Scottsdale or Tempe? The home is just a $10-$15 Uber ride away. I look forward to making your trip to Phoenix so memorable you won't want to leave.

Guest favorite

Guesthouse in Camelback East

4.96 out of 5 average rating, 344 reviews

Modern Guest House in Phoenix/Biltmore Area

This listing was featured on https://news.airbnb.com/the-30-hosts-under-30-class-of-2022/ as a Top 30 host/ listing in the United States. Newly built. Quiet neighborhood. Easy parking access on premises up to two vehicles. Seamless self check-in system. Check in at your connivence. Spacious covered patio area. Our AC/ Heat system is top notch and very quiet. Total of 3 TV'S one in the living room and one in each room. HD Netflix subscription included on all. 5G high speed internet.

Guest favorite

Guesthouse in Gilbert

4.96 out of 5 average rating, 293 reviews

Two Bedroom, clean guest house in Gilbert

Clean and new. Close to downtown Gilbert, with a fun night life & lots of restaurants. 20 min from airport. Close to lots of shopping. Easy access to freeways, less than half an hour to downtown Phoenix. Located on an acre of land, it feels like a little bit of country right inside the city. It's a mile from Freestone park, with tennis, b-ball, volleyball, batting range, playgrounds, ponds, small amusement park. My place is good for couples and business travelers. Please no parties!

Superhost

Guesthouse in Paradise Valley Village

4.77 out of 5 average rating, 191 reviews

Scottsdale Guesthouse With an Acre View

*Newly remodeled* Scottsdale guesthouse with private entrance on a grassy acre lot, in a quiet neighborhood. Pool is available to our guests. Located 3.5 miles from Mayo Clinic and 7 minutes from Scottsdale Quarter and Kierland Commons shopping. New floors, new kitchen, and new sleeper sofa. One bedroom with a queen size bed and sleeper sofa in the living room. Washer and dryer. Full kitchen. Fast wifi. Roku TV with Directv premium channels including NFL, NHL, and NBA tickets.

Guest favorite

Guesthouse in Tempe

5 out of 5 average rating, 202 reviews

Guest house built in 2022 with everything you need

Keep it simple at this peaceful downtown Tempe guest house. Enjoy 10% off for stays of a week or more. It's walking distance to Mill Avenue shops and restaurants, and ASU. Park off street and access through your own entrance. The kitchen has a two hob induction stovetop and a microwave convection oven combo if you want to eat in. A private patio with a gas grill is also available for your use. There is a dishwasher and washer dryer for all the comforts of home.