Villa vacation rentals in Isle of Palms
Find and book unique villas on Airbnb
Top-rated villa rentals in Isle of Palms
Guests agree: these villas are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Isle of Palms villa rentals
Villa rentals with a pool
Villa in Saint Helena Island
Sandy Toes Condos
Villa in Saint Helena Island
Little Palm Villa | Oceanfront
Villa in Seabrook Island
Close to beach, pools, golf&tennis +Amenity Card
Villa in Seabrook Island
Upscale Villa, Amenity Included! Dog Friendly
Villa in Seabrook Island
Seabrook Golf View Villa: Pickleball, Bike, Pool
Villa in Seabrook Island
Newly Remodeled Villa, 5 Minute Walk to Beach
Villa in Seabrook Island
Beautiful and Spacious 2 Bedroom Courtside Villa!
Villa in Edisto Island
Waves of Change
Private villa rentals
Villa in Kiawah Island
Lagoon view villa with office, easy walk to beach!
Villa in Edisto Island
Relax in a Happy Place
Villa in Edisto Island
Loft-e-Lagoon *No Cleaning Fee*
Villa in Kiawah Island
Spacious new 2BR Villa across beach near Sanctuary
Villa in Kiawah Island
Clean & Comfortable! Steps to the beach!
Villa in Seabrook Island
711 Spinnaker centrally located to EVERYTHING!
Villa in Johns Island
Beach and Golf Paradise | Vaughan Villa
Villa in Kiawah Island
Centrally Located Villa in Kiawah Island
Luxury villa rentals
Villa in Folly Beach
Luxury 6BR Tropical Oasis, Pool, Steps to Beach
Villa in Seabrook Island
Luxury Seabrook Isl Beach Condo
Villa in Kiawah Island
Ocean Front! Beach is steps away. Clean and Crisp!
Villa in Seabrook Island
Seaside Therapy - An iTrip Vacations Home
Villa in Wild Dunes
Beachfront IOP Villa with Outdoor Pool. Remodeled!
Villa in Kiawah Island
Oceanfront Windswept Villa
Villa in Wild Dunes
Oceanfront Villa in Wild Dunes! Community Pool!
Villa in Kiawah Island
Luxury Penthouse 2 BR 3 Bath Villa with Ocean View
Quick stats about villa rentals in Isle of Palms
Total rentals
70 properties
Rentals with dedicated workspaces
40 properties have a dedicated workspace
Rentals with a pool
70 properties have a pool
Family-friendly rentals
60 properties are a good fit for families
Total number of reviews
1.3K reviews
Nightly prices starting at
$170 before taxes and fees
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- Rentals with a fire pit Isle of Palms
- Condo rentals Isle of Palms
- Rentals with a patio Isle of Palms
- Apartment rentals Isle of Palms
- House rentals Isle of Palms
- Rentals with a kayak Isle of Palms
- Rentals with a washer and dryer Isle of Palms
- Rentals with a hot tub Isle of Palms
- Rentals with beach access Isle of Palms
- Rentals with outdoor seating Isle of Palms
- Rentals with pools Isle of Palms
- Family-friendly rentals Isle of Palms
- Wheelchair accessible rentals Isle of Palms
- Beach condo rentals Isle of Palms
- Luxury rentals Isle of Palms
- Kid-friendly rentals Isle of Palms
- Pet-friendly rentals Isle of Palms
- Fitness-friendly rentals Isle of Palms
- Rentals with a fireplace Isle of Palms
- Waterfront rentals Isle of Palms
- Beachfront rentals Isle of Palms
- Monthly Rentals Isle of Palms
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