Boutique hotel vacation rentals in Iowa

Find and book unique boutique hotel rentals on Airbnb

Top-rated boutique hotel rentals in Iowa

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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Hotel room in Kanawha

5 out of 5 average rating, 14 reviews

The Mainline Depot Pedersen Suite with Bunkroom

You will feel right at home in this charming luxury studio apartment family suite located in an old 1900's Farmer's State Bank, that can sleep up to 8 guests. This unique suite has a queen sized bed, with a stunning antique chandelier, and a separate whimsical bunk-room that sleeps 6. There is a full sized kitchen with quartz counters that has everything you need and an inviting dining room to eat your meals. Snuggle up on the stylish sofa and enjoy the a cozy electric fireplace and cable TV.

Hotel room in Des Moines

Magnificent Sanctuary with Stunning River Views!

Get the most out of your vacation, whether you are traveling for business or pleasure, by staying at our property. We're 10 minutes from Des Moines International Airport off I-235, right next to the Des Moines River. You can stroll to Principal Park, the home of the Iowa Cubs baseball team, the Court Avenue entertainment district, and the craft beer at El Bait Shop. Before exploring the city, enjoy a complimentary hot breakfast. With our free Wi-Fi, you may keep in touch all through your trip.

Hotel room in Kanawha

5 out of 5 average rating, 14 reviews

The Mainline Depot Langevin Suite

You won’t want to leave this charming, one-of-a-kind suite located in an old 1900's Farmer's State Bank. You will feel right at home in this 1 bedroom suite featuring a stunning antique crystal chandelier, kitchenette with granite counter and all the amenities needed. There is also a laptop friendly desk and internet for those who need to work while away from home. The comfortable living room offers a stylish sofa and chair and cable TV. The cozy luxury bedding makes bedtime so inviting!

Hotel room in Ankeny

The Best Spot for a Relaxing Getaway! W/ Pool, Gym

While staying with us, unwind and take advantage of everything the city has to offer. Our property in Ankeny is near I-35. Drake University, Principal Park, and the Iowa State Capitol in Des Moines are all about 15 minutes away. Big Creek State Park, located on Saylorville Lake, is a short 25-minute drive away. The distance to Ankeny Regional Airport will be 10 minutes. Enjoy a complimentary hot breakfast each morning before heading out on a day of adventure. Parking and Wi-Fi are also free.

Hotel room in Allerton

4.67 out of 5 average rating, 9 reviews

Inn of the Six-Toed Cat -- Rosalie Room

Inn of the Six-Toed Cat, where you can take life a little slower at an authentic turn of the century Inn. We have common rooms for guests to relax, read, play games or watch TV/movie. We provide a wonderful breakfast with warm hospitality. Near by is the highly acclaimed Prairie Trails Museum (in Corydon), Bob White park, Round Barn, Amish country, golfing and lost of little antique stores in the neighboring towns. Come enjoy the front porch lifestyle, and let us be your home away from home.

Hotel room in Kanawha

5 out of 5 average rating, 3 reviews

The Mainline Depot Pedersen Suite for 2

You will feel right at home in this charming luxury studio apartment suite located in an old 1900's Farmer's State Bank. This unique suite has a queen sized bed with a stunning antique chandelier. There is a full sized kitchen with quartz counters that has everything you need and an inviting dining room to eat your meals. Snuggle up on the stylish sofa and enjoy the a cozy electric fireplace and cable TV. (See separate listing to include the bunk room that sleeps an additional 6 guests!

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Hotel room in Dubuque

4.7 out of 5 average rating, 10 reviews

Standard Room

Betsy's Room is located in the White House, a refined, elegant colonial revival-style home. Betsy’s, named after the youngest daughter of Bill and Elizabeth, is an elegantly adorned, spacious room with a queen bed and window facing the river. The private bathroom is located across the hall. Enjoy hiking the trail or sit outside and relish views of the Mighty Mississippi from the patio!

Hotel room in Monticello

The Monticello Motel

A boutique 1950’s roadside motel offering upscale amenities like premium snack trays. Including common areas that are ready to unwind in with your friends and family. Rent the entire property for your next small gathering or reserve individual rooms during your next girls trip. This hip spot offers more than just distinctive decor. It’s unlike any motel you’ve never stayed at before!

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Hotel room in Dubuque

4.67 out of 5 average rating, 3 reviews

Riverview Suite

The Majestic River Suite, located in the Grey House, offers a spectacular and breathtaking view of the Mississippi River. This two-room suite has an adjoining seasonal sitting room and sleeping porch great for relaxing and taking in the view of the river by day and stars by night. The suite offers a king bed, a queen bed in the sleeping porch, and a bath with original subway tile.

Hotel room in Waverly

4.38 out of 5 average rating, 8 reviews

Charming Boutique Country Estate with a pool

No detail is overlooked at this charming and upscale country estate to stay. We have an indoor pool, outdoor basketball courts and pickleball courts, Trager grills available for guests use, outdoor dining area. Plenty of space for your furry friends, we're pet friendly and sit on 10 acres right on the edge of Waverly. Outdoor dog park, book your stay today.

Hotel room in Cedar Falls

4.71 out of 5 average rating, 24 reviews

King Sized Jacuzzi Suite- Room 104

Originally built in 1853, The Black Hawk Hotel is one of the oldest continuously operated hotel west of the Mississippi River. The historic building offers 28 carefully curated rooms each decorated with unique era decor and modern amenities. Room 104 is one of our most requested rooms thanks to its comfy king bed, double Jacuzzi, and heated bathroom floor.

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Hotel room in Washington

4.91 out of 5 average rating, 22 reviews

King Suite - Dodici Night Suites

Above the famous Dodici Cafe Restaurant in beautiful downtown Washington, This suite is newly built in 2016. King size bed with sitting area and bath Extra bedroom with queen size bed Other Amenities: Private Bath with Hair Dryer and Bath Products, Air-conditioning, Refrigerator, Microwave, Coffee Maker, Dining Table, TV, Free Wi-Fi