Vacation rentals in Florence County

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Top-rated vacation rentals in Florence County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite

Place to stay in Effingham

4.96 out of 5 average rating, 114 reviews

Gated and Private Catholic Hermitage house

Saint Michael Hermitage and retreat is a serene, gated, private home that is for 1-3 guests looking for a quiet stay while traveling or as a retreat destination. You will self check into your Hermitage after you obtain a gate code. There is a prayer chapel close by on the property. It is pet friendly for a well trained pet. There is Catholic iconography throughout the home. It is warm and inviting. There is a full kitchen, washer/dryer for your convenience and complementary coffee/tea.

Guest favorite

Rental unit in Florence

4.91 out of 5 average rating, 310 reviews

Kuker Carriage House-Sleeps 3-Downtown/Near I95&20

Kuker Carriage House was originally a barn that has been converted into apartments in the heart of the newly revitalized Florence downtown. This first floor unit was just fully renovated and is ready for you to enjoy, whether for a short overnight stop or a longer extended stay. This space is bright and open with lots of natural light and a fully enclosed private courtyard. Queen bed, twin daybed, full bath, Wifi and TV. Walkable to parks and restaurants. Just 4 miles from I95 and I20

Guest favorite

Cottage in Timmonsville

4.97 out of 5 average rating, 864 reviews

*Cottage Near Florence and I-95*

Located just 5 mins from I-95 (exit 153) and 12 minutes from Florence, this quaint cottage sits on 6 acres with private deck, firepit & large back yard in a peaceful, country location. Your pets are welcome (max of 2, please). We offer king bed in master, 3 wall-mounted TV's (two 55” & one 32”), coffee bar with Keurig, strong WiFi. We also use 100% cotton sheets and quilts for your maximum sleeping comfort. Absolutely no smoking ON OUR PROPERTY ($200 extra fee). Come stay with us. 🙂

Guest favorite

Guest suite in Florence

4.86 out of 5 average rating, 462 reviews

Private Apartment 5 Min Away From I-95 & I-20

Please come and enjoy our Guest Apartment in Florence, SC! A great stop for travelers to rest during their trips. Guests will have a private entrance to the apartment that is attached but separate from the main house, where me and my family live. Guest privacy will always be respected. One bedroom has a queen size bed, a second bedroom has a daybed. The bathroom has a tub and shower. The kitchen has a stove/oven. The apartment is cleaned and sanitized after each guest leaves. Thank you!

Guest favorite

Home in Lake City

4.92 out of 5 average rating, 210 reviews

Home Away From Home Apt 3 - A Hidden Gem

Stand Alone (not a part of the main house) 1 Bed-Room Apt. with Full furnished Kitchen, Full Bath, Private Entrance, private bedroom with door, Private Parking. Living Room- Dining Combo. Fully Furnished. High-Speed WI-Fi, 2 ROKU TVs, 1 in BR & 1 in LR, 1/2 way from New York to Miami, Hablamos Espanol, Fresh Brewed In-Room Coffee. Easy 1-mile walk on Main St. to uptown. 23 miles from I-95, 60 miles to Myrtle Beach, 23 miles to Florence, 1&1/2 hours to Charleston and Columbia.

Guest favorite

Farm stay in Timmonsville

4.95 out of 5 average rating, 587 reviews

The Cottage at Dream Acres & Petting Zoo I-95/I-20

The Cottage at Dream Acres is situated with its own private drive on our 8 acre working horse farm located near Florence SC at the I-20/ I-95 corridor, 5 mins off the highway. We are the 1/2 way point between NY & FL. Relax and unwind from a long roadtrip or take a weekend farm-stay getaway. All the amenities of a larger home with the convenience of a smaller space! Family Friendly; sleeps up to 4, newly renovated in 2020, petting zoo, outdoor fire pit, tree swing, picnic table!

Guest favorite

Guesthouse in Florence

4.98 out of 5 average rating, 752 reviews

Boho Private Downtown Stay Near I-95 & Hospital

Comfort, cleanliness, privacy, and personality! Perfect for overnight stays or longer terms. Come enjoy our Boho hideaway in the heart of Florence. Our place has all the amenities of a hotel with the comfort and privacy of your own home including covered parking for two vehicles. We are located within walking distance to downtown Florence and a 5 minute drive to all of the restaurants and shopping that Florence has to offer. Come stay at our guest house and make yourself at home!

Guest favorite

Farm stay in Hemingway

4.96 out of 5 average rating, 184 reviews

Quiet farmhouse near the beach

The best memories are made on the farm. Life is just better away from the hustle and bustle of city lights and busy schedules. Come stay in this recently renovated fourth generation 1950s farmhouse on an 80 acre working farm. Unwind on the porch, walk trails, find millions of years old sharks teeth, build a bonfire, pick blackberries, swim in the ponds, collect walnuts, or just relax while you’re here but don’t forget to wish on a dandelion or a shooting star before you leave.

Guest favorite

Guesthouse in Florence

4.93 out of 5 average rating, 764 reviews

The Cottage by the Pool: Close to Interstates

New floors and paint in January of 2023. Palm Trees, colorful flowers, hammocks and quiet space await in this tropic-like oasis just minutes from I-95/20. Hundreds of reviews acknowledge this idyllic setting. We are a Florence Airbnb favorite for travelers. We offer a queen bed, full bathroom, full sleeper sofa, strong wifi and TV. We even provide breakfast bars and coffee to help you jump start your day as you set off for the next journey. We look forward to hosting you.

Guest favorite

Home in Darlington

4.85 out of 5 average rating, 117 reviews

Located 100 feet from The Darlington Raceway!

This cute little bungalow is located across the street from The Darlington Raceway. Just a few steps puts you at the door of the famous Joe Weatherly Stock Car Museum. We are also within walking distance to Manheim Auto Auction. The Raceway Grill, a favorite of Dale Earnhardt, is located across the street ! If you are here during the week, South of Pearl, Darlington's finest eating establishment, is located in uptown Darlington. WE DO NOT HAVE A STOVE OR WASHER/DRYER

Guest favorite

Treehouse in Marion

5 out of 5 average rating, 223 reviews

Enchanting Treehouse with Modern Amenities

Perched on 20 acres along Catfish Creek, this enchanting tree house allows you to appreciate nature from a birds eye view. Whether it’s kayaking, canoeing, or exploring along the creek; relaxing in the hammocks and swings; engaging in a board game; or roasting marshmallows at the fire pit, Amenities include a full kitchen with full bath, outdoor shower, booth seating in dining table for up to 8, 2 bunk beds and loft style sleeping.

Guest favorite

Guesthouse in Florence

4.92 out of 5 average rating, 174 reviews

Midtown Retreat - Guest House in heart of Florence

A private, relaxing place to stay right in the middle of town. Conveniently located close to all Florence has to offer, this 1-bedroom guest house is nestled among the trees behind the main house. Located in a beautiful, quiet neighborhood, yet within a few minutes to restaurants, grocery stores, fitness centers, McLeod and MUSC Medical Centers, and more.