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Boutique hotel vacation rentals in Appalachian Mountains

Find and book unique boutique hotel rentals on Airbnb

Top-rated boutique hotel rentals in Appalachian Mountains

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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Hotel room in York

4.81 out of 5 average rating, 1,151 reviews

York Harbor Inn- Country Inn Room

Located on the 2nd & 3rd floors of the Main Inn our Country Inn Rooms are quite small but elegantly appointed. All rooms are individually decorated with (1) queen bed, private baths with shower & standard amenities. These rooms have small bathrooms & dormers. Rooms include our Country Inn breakfast & wifi. These rooms do not have an ocean view but beach is within walking distance. *Not suitable for travel cribs or cots, 2 guests max.* **Please note there are NO ELEVATORS in any of our buildings

Hotel room in Muskegon

4.92 out of 5 average rating, 385 reviews

Downtown • Contemporary • Getaway Waterview Room 2

An old train depot renovated into Muskegon's most luxurious boutique hotel. The space boasts 3 guest rooms, all with private entrances and bathrooms with high end fixtures. Each room is charming with exposed brick and original architectural features throughout. Modern touches give the space a fresh, clean feel. Each room has a wet bar with glassware provided as well as a mini fridge. Located across the street from Muskegon Lake and in walking distance to downtown restaurants, bars and shops.

Hotel room in Rehoboth Beach

4.99 out of 5 average rating, 103 reviews

Starfish Room - Pool, Hot Tub, Sauna

No kids, no pets. The Starfish Room is a coastal-themed, split-level luxury bedroom with a private ensuite bathroom. The bedroom has a king-size bed and there's a seating area with comfy chairs. Enjoy the large in-ground pool, the huge jetted spa/hot tub and Himalayan salt sauna. 10 minutes to the Rehoboth Beach boardwalk, just minutes from a wide array of great dining and 130 outlet stores, a short hop to Cape Henlopen State Park, Lewes, Dewey beach and much more. It's time to hit the beach!

Hotel room in Warsaw

4.96 out of 5 average rating, 113 reviews

Thiel Hospitality House - Room 303

Nestled in the rural hills of Warsaw, this comfortable and quiet house awaits you. A fully-equipped kitchen and charming sun-lit reading area with cozy fireplace are available to gather with other guests for meals and relaxation, and our spacious veranda offers views of the beautiful pastoral valley. Shops and restaurants are just minutes away. NOTICE - If you arrive after dark, we can be a bit tricky to find. We will NOT refund any stays interrupted due to the inability to locate us.

Hotel room in East Aurora

4.93 out of 5 average rating, 361 reviews

The Lofts @ 42 - Queen City Room

The Lofts@42 offer the unique experience of lodging inside an actual production brewery. 42 North Brewing Company is located in the historic village of East Aurora, NY. This type of "brewcation" is one-of a-kind in the state of New York. The Queen City Room features decor representing historic, industrial Buffalo. Images from the city's grain silos and original molds from the Buffalo Foundry & Machine Co. adorn the walls. A juliet balcony overlooks the brewery's beer garden below.

Hotel room in Cape Charles

4.99 out of 5 average rating, 258 reviews

The Laughing King Retreat, Parramore Island Suite

The Laughing King Retreat is an adults-only, organic waterfront farm situated directly on the peaceful waters of Chesapeake Bay. Your private guest suite will enjoy breathtaking sunrises and sunsets, private waterfront pool, private beach, hiking trails, miles of soft sugar sand sandbars to explore and enjoy. Private Chesapeake Bay water access for boating, swimming, paddle boarding, fishing or just soaking. Dig for clams, collect wild oysters, or just sit and marvel at the beauty.

Hotel room in Warwick

4.88 out of 5 average rating, 117 reviews

The Warwick Inn Boutique Little York Loft.

Experience the charm of historic Warwick while enjoying modern amenities and classic comfort in the beautiful Warwick Inn. With origins dating back to the 1850’s this elegant home is filled with old-world appeal and attractive renovations. Feature a comfortable king-sized bed, private bathroom and a pull out couch. Easily explore all that Warwick has to offer including shopping, restaurants, breweries, orchards and more while staying just one block away from downtown Warwick.

Hotel room in West Cape May

4.92 out of 5 average rating, 136 reviews

Buttonwood Boutique Hotel - Cottage Suite A

The Buttonwood Boutique Hotel is a wonderful destination for visitors to Cape May! Its convenient location with a short 10 minute walk to the beaches, restaurants, & shopping, coupled with the historic charm & private suites, make it an enticing choice for travelers seeking a memorable experience. The communal spaces provide opportunities for guests to relax & socialize, enhancing the overall atmosphere of hospitality and warmth. You will feel right at home during your stay!

Hotel room in Afton

4.89 out of 5 average rating, 27 reviews

Suite 6 at Afton Mountain Inn: Private Hot Tub

Come experience a relaxing country getaway filled with romance, breathtaking scenery, charming wineries, outdoor adventure, and quality time with friends and family in the picturesque Blue Ridge Mountains. Located in the heart of Central Virginia’s wine and craft beer country, Afton Mountain Inn is the ideal destination for those looking to explore the surrounding area. Our historic 10-acre estate is surrounded by more than two dozen award-wining wineries and breweries.

Hotel room in Rochester

4.88 out of 5 average rating, 380 reviews

Rest Urban Micro Inn Unit U2

Our place is close to restaurants, coffee shops, independent film movie theater, family-friendly activities, nightlife, and public transport. You’ll love my place because of the location, ambiance, the comfy bed, and the neighborhood. My place is good for couples, solo adventurers, business travelers, families (with kids), and big groups (we have SEVEN completely independent rooms with all amenities each). Think of a mini Hotel thats complete self serve like Yotel NYC.

Hotel room in Niagara Falls

4.9 out of 5 average rating, 147 reviews

Modern Reclaimed King Studio Loft in Niagara Falls

We're your home away from home in the heart of Niagara Falls. Come stay with us at The Cannery Lofts Niagara and feel the energy of our brand-new loft rooms located in a historic, reclaimed 1900s warehouse. Featuring 15-foot ceilings, exposed concrete walls, and modern and spacious bathrooms. This unit features a kitchen including a full-sized refrigerator, convection microwave, and induction cooktop. We provide fresh towels and complimentary toiletries.

Hotel room in Bar Harbor

4.87 out of 5 average rating, 595 reviews

Downtown Hotel Room

Cozy hotel rental at the Acadia Hotel-Downtown. Built in 1884 as a private home, located in the village Center. Private room with full bathroom, QUEEN size bed, cable tv, mini fridge, & wifi. Quite, clean, and the best price in town. These rooms tend to be on the smaller size, and do have SMALL bathrooms. If you are looking for a larger space, look for our Suite Airbnb listing, or book direct though the hotel.

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Luxurious estates for the ultimate escape

Popular amenities for Appalachian Mountains boutique hotel rentals

Free parking on premises

Air conditioning

Family-friendly boutique hotels rentals

Hotel room in Barrie

4.7 out of 5 average rating, 182 reviews

Where 1885 Meets 21st Century Suite Comfort Rm 209

Hotel room in Buxton

4.94 out of 5 average rating, 33 reviews

Periwinkle - Soundfront Queen

Hotel room in Caledon

4.89 out of 5 average rating, 136 reviews

Cheltenham Suites - The Escarpment Suite

Hotel room in Charlottesville

4.74 out of 5 average rating, 199 reviews

Townsman Hotel | Poe Room

Hotel room in Saint John

4.9 out of 5 average rating, 289 reviews

Fitzgerald

Hotel room in Bardstown

4.9 out of 5 average rating, 135 reviews

Luxurious Suite w/garden on Court Square Downtown

Hotel room in Davenport

4.73 out of 5 average rating, 178 reviews

The Davemport Inn Room number 5

Hotel room in New York

4.77 out of 5 average rating, 124 reviews

The Cozy Cole room at The Harlem Flophouse

Boutique hotels rentals with a patio

Hotel room in Rodanthe

4.92 out of 5 average rating, 37 reviews

NEW Wellness Focused Adult Only Boutique Hotel

Hotel room in Niagara-on-the-Lake

5 out of 5 average rating, 22 reviews

Diana Suite

Hotel room in Metamora

4.9 out of 5 average rating, 20 reviews

Khaki Suite

Hotel room in Kingston

4.98 out of 5 average rating, 62 reviews

Grace and Favor - welcoming one bedroom suite

Hotel room in Williamsburg

5 out of 5 average rating, 57 reviews

Armistead House - Room 203 (2nd Floor)

Hotel room in Martinsburg

4.9 out of 5 average rating, 49 reviews

The Peaceful Suite

Hotel room in Bemus Point

5 out of 5 average rating, 29 reviews

Splash Suites ~Brand New~ Heart of Bemus, Suite# 3

Hotel room in Lincoln

4.97 out of 5 average rating, 91 reviews

Suite #3 in the Heart of Beamsville’s Wine Route

Monthly boutique hotels rentals

Hotel room in Meyersdale

4.73 out of 5 average rating, 107 reviews

Anonymous Bunk-GAP Trail Hotel at Morguen Toole Co

Hotel room in Grafton

4.89 out of 5 average rating, 65 reviews

SAGE room ( upstairs)

Hotel room in Myrtle Beach

3.88 out of 5 average rating, 144 reviews

OCEAN VIEW Aventura on the Ocean Double Room

Hotel room in Kenbridge

4.78 out of 5 average rating, 45 reviews

Adorable Efficiency Suite-2- Heart of Kenbridge!

Hotel room in Salem

4.94 out of 5 average rating, 17 reviews

King Suite - The Lofts at Downtown Salem

Hotel room in Grafton

4.93 out of 5 average rating, 121 reviews

Maritime room ( upstairs)

Hotel room in Atlanta

4.2 out of 5 average rating, 5 reviews

The Belize Room Rental @ The GotoATL Guesthouse

Hotel room in Shabbona

4.67 out of 5 average rating, 12 reviews

Historic Shabbona Hotel 16

Destinations to explore