Guesthouse vacation rentals in Charleston
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Charleston
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Charleston guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Charleston
4.99 out of 5 average rating, 264 reviewsSpacious Daniel Island Apartment
Guesthouse in Ridgeville
4.82 out of 5 average rating, 215 reviewsPond House Bungalow at Natural Gathering Grounds
Guesthouse in Charleston
4.91 out of 5 average rating, 650 reviewsIsland OasisβNear Downtown
Guesthouse in North Charleston
5.0 out of 5 average rating, 113 reviewsThe Park Circle Clerestory Studio Guest House
Guesthouse in North Charleston
4.86 out of 5 average rating, 443 reviewsPark Circle Jungalow Loft
Guesthouse in Johns Island
4.98 out of 5 average rating, 240 reviewsPrivate waterfront apt in the oaks
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 100 reviews5 STAR 1bd/1ba Shem Creek Retreat in #1 MtP area!
Guesthouse in Summerville
4.94 out of 5 average rating, 214 reviewsNina's Cottage -Historic Downtown Summerville
Guest house rentals with a patio
Guesthouse in Charleston
4.97 out of 5 average rating, 131 reviewsStudio Apartment Minutes to Downtown Charleston
Guesthouse in Johns Island
4.91 out of 5 average rating, 111 reviewsCozy Cottage! 5 mins from Kiawah!
Guesthouse in Charleston
4.98 out of 5 average rating, 127 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Guesthouse in Hanahan
4.99 out of 5 average rating, 81 reviewsThe Violet Villa w/ no cleaning fee
Guesthouse in Charleston
4.94 out of 5 average rating, 81 reviewsSpacious 1 bedroom cottage in Avondale
Guesthouse in Charleston
4.95 out of 5 average rating, 93 reviewsBoHo styled casita in adorable neighborhood...
Guesthouse in Goose Creek
4.96 out of 5 average rating, 50 reviewsThe Blue Secret
Guesthouse in Charleston
5.0 out of 5 average rating, 25 reviews1/1 sleeps 3 ADU Modern+Amazing!
Guest house rentals with a washer and dryer
Guesthouse in Charleston
4.99 out of 5 average rating, 147 reviewsLarge Guesthouse with Private Dock & Marsh Views
Guesthouse in Charleston
4.99 out of 5 average rating, 209 reviewsRedesigned suite! 12min to city, pet-friendly
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 441 reviewsOld Mt. Pleasant/Shem Creek close to Sullivans/DT
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 259 reviews#1 SC AIRBNB IN MT. PLEASANT OLD VILLAGE. BEACHES!
Guesthouse in Charleston
5.0 out of 5 average rating, 221 reviewsJames Island "La Casita" Nestled btw Beach & City
Guesthouse in Charleston
4.98 out of 5 average rating, 245 reviewsDetached Guest Suite
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 251 reviewsUpscale Couple's Escape | Beach & Downtown CHS
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 119 reviewsBeach, downtown, Alhambra Hall weddings so close!
Quick stats about guesthouse rentals in Charleston
Total rentals
230 properties
Rentals with dedicated workspaces
100 properties have a dedicated workspace
Rentals with a pool
10 properties have a pool
Pet-friendly rentals
50 properties allow pets
Family-friendly rentals
40 properties are a good fit for families
Total number of reviews
23K reviews
Destinations to explore
- SavannahΒ Vacation rentals
- Hilton Head IslandΒ Vacation rentals
- Kiawah IslandΒ Vacation rentals
- Tybee IslandΒ Vacation rentals
- Folly BeachΒ Vacation rentals
- Surfside BeachΒ Vacation rentals
- Mount PleasantΒ Vacation rentals
- Hilton HeadΒ Vacation rentals
- BeaufortΒ Vacation rentals
- Isle of PalmsΒ Vacation rentals
- AtlantaΒ Vacation rentals
- Myrtle BeachΒ Vacation rentals
- Guesthouse rentalsΒ United States
- House rentalsΒ United States
- Apartment rentalsΒ Charleston
- Hotel rentalsΒ Charleston
- Rentals with an EV chargerΒ Charleston
- Rentals with a hot tubΒ Charleston
- Waterfront rentalsΒ Charleston
- Rentals with breakfastΒ Charleston
- Beach condo rentalsΒ Charleston
- Beach house rentalsΒ Charleston
- Rentals with outdoor seatingΒ Charleston
- Pet-friendly rentalsΒ Charleston
- Rentals with a kayakΒ Charleston
- Bungalow rentalsΒ Charleston
- Kid-friendly rentalsΒ Charleston
- Townhouse rentalsΒ Charleston
- Condo rentalsΒ Charleston
- Rentals with beach accessΒ Charleston
- Villa rentalsΒ Charleston
- Family-friendly rentalsΒ Charleston
- Monthly RentalsΒ Charleston
- Rentals with a washer and dryerΒ Charleston
- Beachfront rentalsΒ Charleston
- Fitness-friendly rentalsΒ Charleston
- Rentals with an accessible height toiletΒ Charleston
- Private suite rentalsΒ Charleston
- Mansion rentalsΒ Charleston
- Rentals with poolsΒ Charleston
- Rentals with a fire pitΒ Charleston
- Smoking-friendly rentalsΒ Charleston
- House rentalsΒ Charleston
- Bed and breakfastsΒ Charleston
- Rentals with a fireplaceΒ Charleston
- Luxury rentalsΒ Charleston
- Rentals with lake accessΒ Charleston
- Rentals with a patioΒ Charleston
- House rentalsΒ Myrtle Beach
- House rentalsΒ Savannah
- Guesthouse rentalsΒ Savannah
- House rentalsΒ Hilton Head Island
- Guesthouse rentalsΒ South Carolina
- House rentalsΒ South Carolina
- Guesthouse rentalsΒ Charleston County
- House rentalsΒ Charleston County
- Yurt RentalsΒ United States
- Yurt RentalsΒ United Kingdom
- Castle RentalsΒ United States
- HouseboatsΒ United States
- Holiday CaravansΒ United Kingdom
- Private Island RentalsΒ United States
- Farm HousesΒ United States
- Farm CottagesΒ United Kingdom
- Cabin RentalsΒ Australia
- Luxury CabinsΒ United Kingdom
- Luxury CabinsΒ United States
- Holiday ChaletsΒ United Kingdom
- Cottage RentalsΒ United States
- Holiday CottagesΒ United Kingdom
- Mansion RentalsΒ United States
- Villa RentalsΒ United Kingdom
- Holiday BungalowsΒ United Kingdom
- Bungalow RentalsΒ United States
- Condo RentalsΒ United States
- Holiday ApartmentsΒ Australia
- Holiday HousesΒ United States
- Holiday HousesΒ United Kingdom
- Private Holiday RentalsΒ United Kingdom
- Big House RentalsΒ United States
- Big CottagesΒ Australia
- Large VillasΒ United Kingdom
- House Rentals with a PoolΒ United States
- Cabin Rentals with a PoolΒ United States
- Villas with a PoolΒ United Kingdom
- Apartments with a Hot TubΒ United States
- Holiday Cottages with a Hot TubΒ United Kingdom
- Beach CabinsΒ United States
- Beach CondosΒ United States
- Beachfront RentalsΒ United States
- Beach HousesΒ United Kingdom
- Beach VillasΒ United Kingdom
- Coastal CottagesΒ United Kingdom
- Pet-Friendly Vacation RentalsΒ United States
- Pet-Friendly Beach RentalsΒ United States
- Pet-Friendly Cabin RentalsΒ United States
- Dog-Friendly CottagesΒ United Kingdom
- Luxury Dog-Friendly CottagesΒ United Kingdom